Nickel-catalyzed intermolecular domino reactions

Nickel-catalyzed multiple-component reactions are a promising new type of domino reaction. For instance, a variety of starting materials such as alkenes, alkynes, and unsaturated carbonyl compounds can be connected with high selectivity under reasonably mild conditions. These reactions provide a new route to synthetically important key compounds including dienes, enynes, enol silyl ethers, and carbocycles. Furthermore, an asymmetric version of the reaction is successful. Thus, intermolecular domino reactions should be important reactions for years to come.