Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease

被引：49

作者：

Barrantes, Francisco J. ^{[1
]}

Borroni, Virginia ^{[1
]}

Valles, Sofia ^{[1
]}

机构：

[1] UNESCO, Chair Biophys & Mol Neurobiol, Inst Invest Bioquim Bahia Blanca, Bahia Blanca, Buenos Aires, Argentina

来源：

FEBS LETTERS | 2010年 / 584卷 / 09期

关键词：

Cholesterol; Acetylcholine receptor; Alzheimer's disease; Synapse; Receptor; Nicotinic; AMYLOID PRECURSOR PROTEIN; E-DERIVED PEPTIDES; APOLIPOPROTEIN-E; A-BETA; LIPID RAFTS; TRANSGENIC MODEL; TAU PATHOLOGY; SH-SY5Y CELLS; MOUSE MODEL; IN-VITRO;

D O I：

10.1016/j.febslet.2009.11.036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease (AD) is one of the most devastating diseases of the central nervous system (CNS). It is characterized by two neuropathological findings: amyloid plaques and neurofibrillary tangles. AD is also accompanied by an extensive functional deficit in the cholinergic system, involving the neuronal-type nicotinic acetylcholine receptor (AChR). Furthermore there is increasing evidence showing a misregulation of cholesterol metabolism in the development of the disease. Since cholesterol affects AChR protein at multiple levels, the cognitive impairment and other neurological correlates of AD might be partly associated with an abnormal crosstalk between the receptor protein and the sterol in this synaptopathy. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

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页码：1856 / 1863

页数：8

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