An overview of pharmaceutical cocrystals as intellectual property

被引:314
作者
Trask, Andrew V. [1 ]
机构
[1] Jones Day, New York, NY 10017 USA
关键词
pharmaceutical; cocrystal; solid form; polymorph; intellectual property; patent; legal; regulatory;
D O I
10.1021/mp070001z
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
This review article focuses on the interaction among certain scientific, legal, and regulatory aspects of pharmaceutical crystal forms. The article offers an analysis of pharmaceutical cocrystals as patentable inventions by drawing upon recent scientific developments in the field. Several potential commercial advantages of pharmaceutical cocrystals are highlighted, and a number of recent court decisions involving salient issues are summarized. The article provides an outlook on how the developing field of cocrystallization may impact the pharmaceutical intellectual property landscape.
引用
收藏
页码:301 / 309
页数:9
相关论文
共 55 条
[1]  
Aakeröy CB, 2001, ANGEW CHEM INT EDIT, V40, P3240, DOI 10.1002/1521-3773(20010903)40:17<3240::AID-ANIE3240>3.0.CO
[2]  
2-X
[3]   Crystal engineering: Strategies and architectures [J].
Aakeroy, CB .
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1997, 53 :569-586
[4]   The Cambridge Structural Database: a quarter of a million crystal structures and rising [J].
Allen, FH .
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 2002, 58 (3 PART 1) :380-388
[5]   Systematic analysis of the probabilities of formation of bimolecular hydrogen-bonded ring motifs in organic crystal structures [J].
Allen, FH ;
Motherwell, WDS ;
Raithby, PR ;
Shields, GP ;
Taylor, R .
NEW JOURNAL OF CHEMISTRY, 1999, 23 (01) :25-34
[6]   Crystal engineering of the composition of pharmaceutical phases.: Do pharmaceutical co-crystals represent a new path to improved medicines? [J].
Almarsson, Ö ;
Zaworotko, MJ .
CHEMICAL COMMUNICATIONS, 2004, (17) :1889-1896
[7]  
[Anonymous], 2002, HDB PHARM SALTS PROP, DOI DOI 10.1002/jps.22405
[8]  
Barnes R. D., 1988, U.S. Patent, Patent No. [4,721,723, 4721723, US4721723A]
[9]   Pharmaceutical cocrystal and salts of norfloxacin [J].
Basavoju, Srinivas ;
Bostrom, Dan ;
Velaga, Sitaram P. .
CRYSTAL GROWTH & DESIGN, 2006, 6 (12) :2699-2708
[10]  
Bernstein J., 2002, POLYMORPHISM MOL CRY, P297