An overview of pharmaceutical cocrystals as intellectual property

被引：314

作者：

Trask, Andrew V. ^{[1
]}

机构：

[1] Jones Day, New York, NY 10017 USA

来源：

MOLECULAR PHARMACEUTICS | 2007年 / 4卷 / 03期

关键词：

pharmaceutical; cocrystal; solid form; polymorph; intellectual property; patent; legal; regulatory;

D O I：

10.1021/mp070001z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This review article focuses on the interaction among certain scientific, legal, and regulatory aspects of pharmaceutical crystal forms. The article offers an analysis of pharmaceutical cocrystals as patentable inventions by drawing upon recent scientific developments in the field. Several potential commercial advantages of pharmaceutical cocrystals are highlighted, and a number of recent court decisions involving salient issues are summarized. The article provides an outlook on how the developing field of cocrystallization may impact the pharmaceutical intellectual property landscape.

引用

收藏

页码：301 / 309

页数：9

相关论文

共 55 条

[11]

Bighley L.D., 1996, Encyclopedia of Pharmaceutical Technology, V13, P453

[12]

Bond AD, 2007, ANGEW CHEM INT EDIT, V46, P618, DOI 10.1002/anie.200603373

[13]

Byrn S.R., 1999, Solid State Chemistry of Drugs, VSecond

[14] Prediction and observation of isostructurality induced by solvent incorporation in multicomponent crystals [J].

Cabeza, Aurora J. Cruz ;

Day, Graeme M. ;

Motherwell, W. D. Samuel ;

Jones, William .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (45) :14466-14467

[15] SELECTIVE FORMATION OF HYDROGEN-BONDED COCRYSTALS BETWEEN A SULFONAMIDE AND AROMATIC CARBOXYLIC-ACIDS IN THE SOLID-STATE [J].

CAIRA, MR ;

NASSIMBENI, LR ;

WILDERVANCK, AF .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1995, (12) :2213-2216

[16] Dealing with the impact of ritonavir polymorphs on the late stages of bulk drug process development [J].

Chemburkar, SR ;

Bauer, J ;

Deming, K ;

Spiwek, H ;

Patel, K ;

Morris, J ;

Henry, R ;

Spanton, S ;

Dziki, W ;

Porter, W ;

Quick, J ;

Bauer, P ;

Donaubauer, J ;

Narayanan, BA ;

Soldani, M ;

Riley, D ;

McFarland, K .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2000, 4 (05) :413-417

[17] Development of a pharmaceutical cocrystal of a monophosphate salt with phosphoric acid [J].

Chen, Alex M. ;

Ellison, Martha E. ;

Peresypkin, Andrey ;

Wenslow, Robert M. ;

Variankaval, Narayan ;

Savarin, Cecile G. ;

Natishan, Theresa K. ;

Mathre, David J. ;

Dormer, Peter G. ;

Euler, Danielle H. ;

Ball, Richard G. ;

Ye, Zhixiong ;

Wang, Yaling ;

Santos, Ivan .

CHEMICAL COMMUNICATIONS, 2007, (04) :419-421

[18] Crystal engineering approach to forming cocrystals of amine hydrochlorides with organic acids. Molecular complexes of fluoxetine hydrochloride with benzoic, succinic, and fumaric acids [J].

Childs, SL ;

Chyall, LJ ;

Dunlap, JT ;

Smolenskaya, VN ;

Stahly, BC ;

Stahly, GP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (41) :13335-13342

[19] Crystal structures of drugs: Advances in determination, prediction and engineering [J].

Datta, S ;

Grant, DJW .

NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (01) :42-57

[20] Investigating the latent polymorphism of maleic acid [J].

Day, GM ;

Trask, AV ;

Motherwell, WDS ;

Jones, W .

CHEMICAL COMMUNICATIONS, 2006, (01) :54-56

← 1 2 3 4 5 6 →