Development of a pharmaceutical cocrystal of a monophosphate salt with phosphoric acid

被引：84

作者：

Chen, Alex M.

Ellison, Martha E.

Peresypkin, Andrey

Wenslow, Robert M.

Variankaval, Narayan

Savarin, Cecile G.

Natishan, Theresa K.

Mathre, David J.

Dormer, Peter G.

Euler, Danielle H.

Ball, Richard G.

Ye, Zhixiong

Wang, Yaling

Santos, Ivan

机构：

[1] Merck & Co Inc, Rahway, NJ 07065 USA

[2] Merck & Co Inc, West Point, PA 19486 USA

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 04期

关键词：

D O I：

10.1039/b612353h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the first case of a pharmaceutical cocrystal formed between an inorganic acid and an active pharmaceutical ingredient (API), which enabled us to develop a stable crystalline and bioavailable solid dosage form for pharmaceutical development where otherwise only unstable amorphous free form or salts could have been used.

引用

收藏

页码：419 / 421

页数：3

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