Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack

被引:188
作者
Brown, Maile R. [1 ]
Kronengold, Jack [1 ]
Gazula, Valeswara-Rao [1 ]
Chen, Yi [2 ]
Strumbos, John G. [1 ]
Sigworth, Fred J. [2 ]
Navaratnam, Dhasakumar [3 ,4 ]
Kaczmarek, Leonard K. [1 ,2 ]
机构
[1] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06510 USA
[3] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA
[4] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06510 USA
基金
美国国家卫生研究院;
关键词
AUDITORY NEURONS; TRANSLATION; GENE; RNA;
D O I
10.1038/nn.2563
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In humans, the absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein, results in Fragile X syndrome, the most common inherited form of intellectual disability. Using biochemical and electrophysiological studies, we found that FMRP binds to the C terminus of the Slack sodium-activated potassium channel to activate the channel in mice. Our findings suggest that Slack activity provides a link between patterns of neuronal firing and changes in protein translation.
引用
收藏
页码:819 / 821
页数:3
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