Neurotrophins: Neurotrophic modulation of neurite growth

被引:72
作者
Davies, AM [1 ]
机构
[1] Univ St Andrews, Sch Biol, St Andrews KY16 9TS, Fife, Scotland
关键词
D O I
10.1016/S0960-9822(00)00351-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
As well as regulating neuronal survival, neurotrophins control the growth of axons and dendrites. New light has been shed on the mechanism of this latter control process by the discovery that the common neurotrophin receptor p75(NTR) interacts in a ligand-dependent manner with RhoA, a known regulator of actin assembly.
引用
收藏
页码:R198 / R200
页数:3
相关论文
共 19 条
[1]   NERVE GROWTH-FACTOR AND ITS LOW-AFFINITY RECEPTOR PROMOTE SCHWANN-CELL MIGRATION [J].
ANTON, ES ;
WESKAMP, G ;
REICHARDT, LF ;
MATTHEW, WD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (07) :2795-2799
[2]   Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR [J].
Bibel, M ;
Hoppe, E ;
Barde, YA .
EMBO JOURNAL, 1999, 18 (03) :616-622
[3]  
Brann AB, 1999, J NEUROSCI, V19, P8199
[4]   The zinc finger protein NRIF interacts with the neurotrophin receptor p75NTR and participates in programmed cell death [J].
Casademunt, E ;
Carter, BD ;
Benzel, I ;
Frade, JM ;
Dechant, G ;
Barde, YA .
EMBO JOURNAL, 1999, 18 (21) :6050-6061
[5]  
DAVIES AM, 1997, CURR BIOL, V7, P38
[6]   Characterization of a distinctive motif of the low molecular weight neurotrophin receptor that modulates NGF-mediated neurite growth [J].
Dostaler, SM ;
Ross, GM ;
Myers, SM ;
Weaver, DF ;
Ananthanarayanan, V ;
Riopelle, RJ .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1996, 8 (05) :870-879
[7]   DIRECTED EXPRESSION OF NGF TO PANCREATIC BETA-CELLS IN TRANSGENIC MICE LEADS TO SELECTIVE HYPERINNERVATION OF THE ISLETS [J].
EDWARDS, RH ;
RUTTER, WJ ;
HANAHAN, D .
CELL, 1989, 58 (01) :161-170
[8]  
Frade JM, 1998, BIOESSAYS, V20, P137, DOI 10.1002/(SICI)1521-1878(199802)20:2<137::AID-BIES6>3.0.CO
[9]  
2-Q
[10]   p75-mediated NF-κB activation enhances the survival response of developing sensory neurons to nerve growth factor [J].
Hamanoue, M ;
Middleton, G ;
Wyatt, S ;
Jaffray, E ;
Hay, RT ;
Davies, AM .
MOLECULAR AND CELLULAR NEUROSCIENCE, 1999, 14 (01) :28-40