Improved contrast for myeloma focal lesions with T2-weighted Dixon images compared to T1-weighted images

被引：25

作者：

Danner, A. ^{[1
]}

Brumpt, E. ^{[1
,2
]}

Alilet, M. ^{[1
]}

Tio, G. ^{[3
]}

Omoumi, P. ^{[4
]}

Aubry, S. ^{[1
,5
]}

机构：

[1] CHU Besancon, Dept Musculoskeletal Imaging, F-25000 Besancon, France

[2] Univ Bourgogne Franche Comte, Lab Anat, F-25000 Besancon, France

[3] CHU Besancon, INSERM CIT808, Clin Invest Ctr, F-25000 Besancon, France

[4] Lausanne Univ Hosp, Dept Diagnost & Intervent Radiol, CH-1011 Lausanne, Switzerland

[5] Univ Bourgogne Franchecomte, Nanomed Lab, Inserm EA 4662, F-25000 Besancon, France

来源：

DIAGNOSTIC AND INTERVENTIONAL IMAGING | 2019年 / 100卷 / 09期

关键词：

Magnetic resonance imaging (MRI); Multiple myeloma; Dixon sequence; Bone marrow; TAU INVERSION-RECOVERY; BONE-MARROW; MULTIPLE-MYELOMA; FAT-SUPPRESSION; CHEMICAL-SHIFT; MRI; METASTASES; INTENSITY; DIAGNOSIS; HANDS;

D O I：

10.1016/j.diii.2019.05.001

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

Purpose: The purpose of this study was twofold. First, to compare the contrast between spinal multiple myeloma (MM) focal lesions and surrounding bone marrow obtained on T2-weighted Dixon fat-only MR images to that obtained on T1-weighted spin-echo images. Second, to search for correlation between bone marrow fat fraction assessed by T2-weighted Dixon sequence and International Myeloma Working Group myeloma defining events. Materials and methods: A total of 39 patients with 112 focal MM lesions were included. There were 25 men and 14 women with a mean age of 68.8 +/- 9.8 [SD] years (range: 49-88 years). Contrast between focal MM lesions and surrounding bone marrow was calculated on T1-weighted spin-echo and T2-weighted Dixon (including water-only and fat-only) images. Contrast between focal MM lesions and bone marrow was compared using ANOVA and post-hoc Tukey tests. Correlation between bone marrow fat fraction and myeloma defining events was assessed using Spearman's correlation test. Results: MM lesion contrast was greater on T2-weighted Dixon (F (2;93)=35.10) than on T1-weighted images (P< 0.0001). Greatest MM lesion contrast was achieved with T2-weighted Dixon fat-only (0.63 +/- 0.21 [SD]; range: 0.06-0.91) compared to T2-weighted Dixon water-only (0.45 +/- 0.20 [SD]; range: 0.07-0.8) (P=0.0003) and T1-weighted (0.23 +/- 0.19 [SD]; range: 0.04-0.87) (P <0.0001) images. There were no significant correlations between myeloma defining events and fat fraction. Conclusion: T2-weighted Dixon fat-only images provide greater contrast between MM lesions and adjacent bone marrow than T1-weighted images. The usefulness of a T1-weighted sequence associated to a T2-weighted Dixon sequence has to be determined. (C) 2019 Societe francaise de radiologie. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：513 / 519

页数：7

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