Hydrazone Ligation Strategy to Assemble Multifunctional Viral Nanoparticles for Cell Imaging and Tumor Targeting

被引：121

作者：

Brunel, Florence M. ^{[1
,2
]}

Lewis, John D. ^{[1
]}

Destito, Giuseppe ^{[1
,3
,4
]}

Steinmetz, Nicole F. ^{[1
,3
]}

Manchester, Marianne ^{[1
,3
]}

Stuhlmann, Heidi ^{[1
]}

Dawson, Philip E. ^{[1
,2
]}

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Ctr Integrat Mol Biosci, La Jolla, CA 92037 USA

[4] Univ Magna Graecia di Catanzaro, Dipartimento Med Sperimentale & Clin, I-88100 Catanzaro, Italy

来源：

NANO LETTERS | 2010年 / 10卷 / 03期

关键词：

Viral nanoparticle; chemical ligation; cell imaging; tumor targeting; VEGFR-1; COWPEA MOSAIC-VIRUS; EXPRESSION; PROTEIN; GROWTH; DELIVERY; SURFACE; VEGF;

D O I：

10.1021/nl1002526

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multivalent nanoparticle platforms are attractive for biomedical applications because of their improved target specificity, sensitivity, and solubility. However, their controlled assembly remains a considerable challenge, An efficient hydrazone ligation chemistry was applied to the assembly of Cowpea mosaic virus (CPMV) nanoparticles with individually tunable levels of a VEGFR-I ligand and a fluorescent PEGylated peptide. The nanoparticles recognized VEGFR-I on endothelial cell lines and VEGFR I-expressing tumor xenografts in mice, validating targeted CPMV as a nanoparticle platform in vivo.

引用

页码：1093 / 1097

页数：5

共 33 条

[11] Interaction between a 54-kilodalton mammalian cell surface protein and cowpea mosaic virus [J].

Koudelka, Kristopher J. ;

Rae, Chris S. ;

Gonzalez, Maria J. ;

Manchester, Marianne .

JOURNAL OF VIROLOGY, 2007, 81 (04) :1632-1640

[12] Endothelial Targeting of Cowpea Mosaic Virus (CPMV) via Surface Vimentin [J].

Koudelka, Kristopher J. ;

Destito, Giuseppe ;

Plummer, Emily M. ;

Trauger, Sunia A. ;

Siuzdak, Gary ;

Manchester, Marianne .

PLOS PATHOGENS, 2009, 5 (05)

[13] Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1 [J].

Lee, Tae-Hee ;

Seng, Seyha ;

Sekine, Masayuki ;

Hinton, Cimona ;

Fu, Yigong ;

Avraham, Hava Karsenty ;

Avraham, Shalom .

PLOS MEDICINE, 2007, 4 (06) :1101-1116

[14]

Lewis JD, 2006, NAT MED, V12, P354, DOI 10.1038/nm1368

[15] The refined crystal structure of cowpea mosaic virus at 2.8 Å resolution [J].

Lin, TW ;

Chen, ZG ;

Usha, R ;

Stauffacher, CV ;

Dai, JB ;

Schmidt, T ;

Johnson, JE .

VIROLOGY, 1999, 265 (01) :20-34

[16] A NOVEL PROMOTER FOR VASCULAR ENDOTHELIAL GROWTH-FACTOR RECEPTOR (FLT-1) THAT CONFERS ENDOTHELIAL-SPECIFIC GENE-EXPRESSION [J].

MORISHITA, K ;

JOHNSON, DE ;

WILLIAMS, LT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (46) :27948-27953

[17] Looking and listening to light: the evolution of whole-body photonic imaging [J].

Ntziachristos, V ;

Ripoll, J ;

Wang, LHV ;

Weissleder, R .

NATURE BIOTECHNOLOGY, 2005, 23 (03) :313-320

[18] Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy [J].

Oh, P ;

Li, Y ;

Yu, JY ;

Durr, E ;

Krasinska, KM ;

Carver, LA ;

Testa, JE ;

Schnitzer, JE .

NATURE, 2004, 429 (6992) :629-635

[19] PEGylated lysine dendrimers for tumor-selective targeting after intravenous injection in tumor-bearing mice [J].

Okuda, Tatsuya ;

Kawakami, Shigeru ;

Akimoto, Naomi ;

Niidome, Takuro ;

Yamashita, Fumiyoshi ;

Hashida, Mitsuru .

JOURNAL OF CONTROLLED RELEASE, 2006, 116 (03) :330-336

[20] Virus Particle Explorer (VIPER), a Website for virus capsid structures and their computational analyses [J].

Reddy, VS ;

Natarajan, P ;

Okerberg, B ;

Li, K ;

Damodaran, KV ;

Morton, RT ;

Brooks, C ;

Johnson, JE .

JOURNAL OF VIROLOGY, 2001, 75 (24) :11943-11947

← 1 2 3 4 →