Separation of enantiomers of drugs by capillary electrophoresis .3. beta-cyclodextrin as chiral solvating agent

被引：49

作者：

Koppenhoefer, B

Epperlein, U

Christian, B

Lin, B

Ji, Y

Chen, Y

机构：

[1] ACAD SINICA,DALIAN INST CHEM PHYS,DALIAN 116012,PEOPLES R CHINA

[2] CHINA PHARMACEUT UNIV,NANJING 250009,PEOPLES R CHINA

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 735卷 / 1-2期

关键词：

enantiomer separation; buffer composition; drugs; zopiclone; cyclodextrins;

D O I：

10.1016/0021-9673(95)01210-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Enantiomer separation by capillary zone electrophoresis was studied for a set of 34 chiral drugs. Keeping the concentration of beta-cyclodextrin as a chiral solvating agent as constant as possible led to the separation of seven enantiomeric pairs. Carvedilol, Tetryzoline, Tropicamide and Zopiclone gave a baseline separation, Chlorphenamine, Ketamine, and Orciprenaline a partial separation. Statistical analysis revealed that the best separation factors were observed for a medium degree of interaction with the cyclodextrin. A theory explaining this effect provides a helpful guideline for further optimization.

引用

页码：333 / 343

页数：11

共 26 条

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