CHIRAL SEPARATION OF BASIC DRUGS USING CYCLODEXTRINS AS CHIRAL PSEUDO-STATIONARY PHASES IN CAPILLARY ELECTROPHORESIS

被引：123

作者：

HEUERMANN, M ^{[1
]}

BLASCHKE, G ^{[1
]}

机构：

[1] UNIV MUNSTER,DEPT PHARMACEUT CHEM,HITTORFSTR 58-62,D-48149 MUNSTER,GERMANY

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 648卷 / 01期

关键词：

D O I：

10.1016/0021-9673(93)83310-O

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Capillary electrophoresis was used for the chiral resolution of basic racemic drugs in general and in particular for dimethindene and four possible metabolites. Conditions for optimum enantioselectivity and resolution were determined by changing the cyclodextrin type, cyclodextrin concentration, pH of the run buffer, applied current and capillary temperature.

引用

页码：267 / 274

页数：8

共 20 条

[1] CHIRAL SEPARATION OF BETA-AMINO ALCOHOLS BY CAPILLARY ELECTROPHORESIS USING CYCLODEXTRINS AS BUFFER ADDITIVES .1. EFFECT OF VARYING OPERATING PARAMETERS
ALTRIA, KD
GOODALL, DM
ROGAN, MM
[J]. CHROMATOGRAPHIA, 1992, 34 (1-2) : 19 - 24
[2] Brown C, 1990, CHIRALITY DRUG DESIG, P29
[3] ENANTIOMER RESOLUTION BY USING CAPILLARY ZONE ELECTROPHORESIS - RESOLUTION OF RACEMIC TRYPTOPHAN AND DETERMINATION OF THE ENANTIOMER COMPOSITION OF COMMERCIAL PHARMACEUTICAL EPINEPHRINE
FANALI, S
BOCEK, P
[J]. ELECTROPHORESIS, 1990, 11 (09) : 757 - 760
[4] USE OF COMPLEXING AGENTS FOR SELECTIVE SEPARATION IN HIGH-PERFORMANCE CAPILLARY ELECTROPHORESIS - CHIRAL RESOLUTION VIA CYCLODEXTRINS INCORPORATED WITHIN POLYACRYLAMIDE-GEL COLUMNS
GUTTMAN, A
PAULUS, A
COHEN, AS
GRINBERG, N
KARGER, BL
[J]. JOURNAL OF CHROMATOGRAPHY, 1988, 448 (01): : 41 - 53
[5] HEUERMANN M, 1992, 3RD INT S CHIR DISCR
[6] HEUERMANN M, 1992, 4TH INT S HIGH PERF
[7] ZONE ELECTROPHORESIS IN OPEN-TUBULAR GLASS-CAPILLARIES
JORGENSON, JW
LUKACS, KD
[J]. ANALYTICAL CHEMISTRY, 1981, 53 (08) : 1298 - 1302
[8] CHIRAL SEPARATION BY CAPILLARY ELECTROPHORESIS
KUHN, R
HOFFSTETTERKUHN, S
[J]. CHROMATOGRAPHIA, 1992, 34 (9-10) : 505 - 512
[9] DETERMINATION OF ANTIHISTAMINES IN PHARMACEUTICALS BY CAPILLARY ELECTROPHORESIS
ONG, CP
NG, CL
LEE, HK
LI, SFY
[J]. JOURNAL OF CHROMATOGRAPHY, 1991, 588 (1-2): : 335 - 339
[10] PRIEN D, 1992, 3RD INT S CHIR DISCR

← 1 2 →