Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators

被引：20

作者：

Zhi, L ^{[1
]}

Tegley, CM ^{[1
]}

Pio, B ^{[1
]}

Edwards, JP ^{[1
]}

Jones, TK ^{[1
]}

Marschke, KB ^{[1
]}

Mais, DE ^{[1
]}

Risek, B ^{[1
]}

Schrader, WT ^{[1
]}

机构：

[1] Ligand Pharmaceut, Discovery Res, San Diego, CA 92121 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(03)00255-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 5-methylidene 1,2-dihydrochromeno[3,4-]quinoline derivatives were synthesized and tested in biological assays to evaluate scope and limitations of the nonsteroidal SPRM pharmacophore (3). A number of orally available highly potent nonsteroidal modulators were identified by modification of the substituents at 5-methylidene position. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2071 / 2074

页数：4

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