In search of partners: linking extracellular proteases to substrates

被引：258

作者：

Overall, Christopher M.

Blobel, Carl P.

机构：

[1] Univ British Columbia, Ctr Blood Res, CBCRA Program Breast Canc Metastasis, Dept Oral Biol & Med Sci, Vancouver, BC V6T 1Z3, Canada

[2] Univ British Columbia, Ctr Blood Res, CBCRA Program Breast Canc Metastasis, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada

[3] Hosp Special Surg, Arthrit & Tissue Degenerat Program, New York, NY 10021 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 03期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm2120

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proteases function as molecular switches in signalling circuits at the cell surface and in the extracellular milieu. In light of the many proteases that are encoded by the genome, and the even larger number of bioactive substrates, it is crucial to identify which proteases cleave a particular substrate and which substrates individual proteases cleave. Elucidating the substrate degradomes of proteases will help us to understand the function of proteases in development and disease and to validate proteases as drug targets.

引用

页码：245 / 257

页数：13

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