Endocytic control of signaling at the plasma membrane

被引：67

作者：

Barbieri, Elisa ^{[1
]}

Di Fiore, Pier Paolo ^{[1
,2
,3
]}

Sigismund, Sara ^{[1
]}

机构：

[1] Fdn Ist FIRC Oncol Mol, IFOM, Via Adamello 16, I-20139 Milan, Italy

[2] Univ Milan, Dipartimento Sci Salute, Via Rudini 8, I-20122 Milan, Italy

[3] Ist Europeo Oncol, Via Ripamonti 435, I-20141 Milan, Italy

来源：

CURRENT OPINION IN CELL BIOLOGY | 2016年 / 39卷

基金：

欧洲研究理事会;

关键词：

CLATHRIN-COATED PIT; BETA-CATENIN; SINGLE-CELL; INTERNALIZATION; DYNAMICS; LRP6; TRAFFICKING; PATHWAYS; TENSION; SHAPE;

D O I：

10.1016/j.ceb.2016.01.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Signaling is regulated by endocytosis at multiple levels along endocytic routes. Endocytic control of signaling starts already at the plasma membrane, where cells employ different mechanisms to finely tune the type and strength of signals emanating from the cell surface. Here, we will review some of the most recently described endocytic mechanisms controlling signaling at the plasma membrane, through the regulation of internalization dynamics and through the integration of different internalization pathways triggered by canonical chemical stimuli or physical forces.

引用

页码：21 / 27

页数：7

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