Asymmetric total synthesis of natural pyrrolizidine alkaloid, (+)-alexine

被引：47

作者：

Yoda, H ^{[1
]}

Katoh, H ^{[1
]}

Takabe, K ^{[1
]}

机构：

[1] Shizuoka Univ, Fac Engn, Dept Mol Sci, Hamamatsu, Shizuoka 4328561, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 40期

基金：

日本学术振兴会;

关键词：

pyrrolizidine alkaloid; alexine; stereoselective reduction; chiral lactam; D-arabinofuranose;

D O I：

10.1016/S0040-4039(00)01314-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of the potent glycosidase inhibitor (+)-alexine with five contiguous stereogenic centres [(1R,2R,3R,7S,7aS)-3-hydroxymethyl-1,2,7-trihydroxypyrrolizidine alkaloid] is described featuring. the efficient and stereodefined novel elaboration of the functionalized homochiral lactam derived from 2,3,5-tri-O-benzyl-beta-D-arabinofuranose. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7661 / 7665

页数：5

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