PARP inhibition: PARP1 and beyond

被引：1066

作者：

Rouleau, Michele ^{[1
]}

Patel, Anand ^{[2
]}

Hendzel, Michael J. ^{[4
]}

Kaufmann, Scott H. ^{[2
,3
]}

Poirier, Guy G. ^{[1
]}

机构：

[1] Univ Laval, Med Res Ctr, Quebec City, PQ, Canada

[2] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA

[3] Mayo Clin, Div Oncol Res, Rochester, MN USA

[4] Univ Alberta, Fac Med, Dept Oncol, Edmonton, AB T6G 2M7, Canada

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 04期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

POLY(ADP-RIBOSE) POLYMERASE INHIBITOR; ADENOSINE-DIPHOSPHATE-RIBOSE; DOUBLE-STRAND BREAKS; DNA-DAMAGING AGENTS; HUMAN GLIOMA-CELLS; HOMOLOGOUS RECOMBINATION; ADP-RIBOSYLATION; TELOMERE LENGTH; IN-VIVO; EMBRYONIC-DEVELOPMENT;

D O I：

10.1038/nrc2812

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide the rational development of PARP inhibitors as anticancer agents.

引用

收藏

页码：293 / 301

页数：9

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