Oncogenic resistance to growth-limiting conditions

被引：91

作者：

Blagosklonny, MV ^{[1
]}

机构：

[1] Brander Canc Res Inst, New York Med Coll, Dept Med, Hawthorne, NY 10532 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 03期

关键词：

D O I：

10.1038/nrc743

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many carcinogens are mutagens, indicating that mutagenesis is the driving force of carcinogenesis. But what if we turn this prevailing view on its head? I will argue here that carcinogens are cytostatic and/or cytotoxic, and it is not mutation per se, but clonal selection for resistance to these antiproliferative conditions, that leads to cancer. But why aren't all cytotoxins carcinogenic?

引用

页码：221 / 225

页数：5

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