Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion

被引：149

作者：

Critchley, DR ^{[1
]}

机构：

[1] Univ Leicester, Dept Biochem, Leicester LE1 7RH, Leics, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷

关键词：

cytoskeleton; focal adhesions; integrin; talin; vinculin;

D O I：

10.1042/BST0320831

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cytoskeletal proteins talin and vinculin form part of a macromolecular complex on the cytoplasmic face of integrin-mediated cellular junctions with the extracellular matrix. Recent genetic, biochemical and structural data show that talin is essential for the assembly of such junctions, whereas vinculin appears to be important in regulating adhesion dynamics and cell migration.

引用

页码：831 / 836

页数：6

共 70 条

[21] The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility
Fincham, VJ
Frame, MC
[J]. EMBO JOURNAL, 1998, 17 (01) : 81 - 92
[22] NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide - Evidence for a two-site binding model
Gao, GH
Prutzman, KC
King, ML
Scheswohl, DM
DeRose, EF
London, RE
Schaller, MD
Campbell, SL
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (09) : 8441 - 8451
[23] Structural determinants of integrin recognition by Talin
García-Alvarez, B
de Pereda, JM
Calderwood, DA
Ulmer, TS
Critchley, D
Campbell, ID
Ginsberg, MH
Liddington, RC
[J]. MOLECULAR CELL, 2003, 11 (01) : 49 - 58
[24] Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation
Giannone, G
Jiang, G
Sutton, DH
Critchley, DR
Sheetz, MP
[J]. JOURNAL OF CELL BIOLOGY, 2003, 163 (02) : 409 - 419
[25] Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate
Gilmore, AP
Burridge, K
[J]. NATURE, 1996, 381 (6582) : 531 - 535
[26] Restructuring of focal adhesion plaques by PI 3-kinase:: Regulation by PtdIns (3,4,5)-P3 binding to α-actinin
Greenwood, JA
Theibert, AB
Prestwich, GD
Murphy-Ullrich, JE
[J]. JOURNAL OF CELL BIOLOGY, 2000, 150 (03) : 627 - 641
[27] HAGMANN J, 1992, J BIOL CHEM, V267, P14424
[28] The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin
Hayashi, I
Vuori, K
Liddington, RC
[J]. NATURE STRUCTURAL BIOLOGY, 2002, 9 (02) : 101 - 106
[29] Hemmings L, 1996, J CELL SCI, V109, P2715
[30] Characterization of two F-actin-binding and oligomerization sites in the cell-contact protein vinculin
Huttelmaier, S
Bubeck, P
Rudiger, M
Jockusch, BM
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 247 (03): : 1136 - 1142

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