The role of ascorbic acid on the redox status and the concentration of malondialdehyde in streptozotocin-induced diabetic rats

被引：6

作者：

Choi, HJ ^{[1
]}

Je, HD ^{[1
]}

Jeong, JH ^{[1
]}

Min, YS ^{[1
]}

Choi, TS ^{[1
]}

Park, JH ^{[1
]}

Shin, CY ^{[1
]}

Sohn, UD ^{[1
]}

机构：

[1] Chung Ang Univ, Coll Pharm, Dept Pharmacol, Seoul 156756, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2003年 / 26卷 / 03期

关键词：

diabetes mellitus; malondialdehyde; ascorbic acid; redox status;

D O I：

10.1007/BF02976836

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We investigated the role of ascorbic acid on the redox status in streptozotocin-induced diabetic rats. In the plasma of diabetic rats, the ratio of reduced/total ascorbic acid was significantly decreased as compared with normal control. Ascorbic acid supplementation increased the reduced and total ascorbic acid contents as compared with diabetic control. In the rutin-treatment group, reduced and total contents of ascorbic acid were significantly decreased, however, the ratio of reduced/total contents of ascorbic acid had no difference as compared with diabetic rats. In the insulin-treatment group, this ratio is not significantly different as com,pared with diabetic control. However, in the insulin plus ascorbic acid treatment group, reduced form and the ratio of reduced/total ascorbic acid were significantly increased as compared with diabetic control. In addition, we measured the contents of malondialdehyde (MDA) in the plasma of diabetic rats. The contents of MDA was increased as compared with normal control, however, in insulin-treatment group, the contents of MDA was decreased as compared with diabetic rats. Ascorbic acid had no effects on the increases of MDA in diabetic rats. In conclusion, plasma ascorbic acid level and its reduced/total ratio reflects the status of the oxidative stress in the diabetic rats. Supplement of ascorbic acid did not correct the ratio of the reduced/total ascorbic acid. However, supplement of insulin and ascorbic acid corrected the ratio of reduced/total ascorbic acid.

引用

页码：237 / 243

页数：7

共 36 条

[21] Solution structure of an engineered insulin monomer at neutral pH [J].