Lysosomes: fusion and function

被引:1313
作者
Luzio, J. Paul
Pryor, Paul R.
Bright, Nicholas A.
机构
[1] Univ Cambridge, Cambridge Inst Med Res, Addenbrookes Hosp, Cambridge CB2 0XY, England
[2] Univ Cambridge, Dept Clin Biochem, Addenbrookes Hosp, Cambridge CB2 0XY, England
[3] Univ York, Dept Biol, Area 9, York YO10 5YW, N Yorkshire, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1038/nrm2217
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Lysosomes are dynamic organelles that receive and degrade macromolecules from the secretory, endocytic, autophagic and phagocytic membrane- trafficking pathways. Live-cell imaging has shown that fusion with lysosomes occurs by both transient and full fusion events, and yeast genetics and mammalian cell-free systems have identified much of the protein machinery that coordinates these fusion events. Many pathogens that hijack the endocytic pathways to enter cells have evolved mechanisms to avoid being degraded by the lysosome. However, the function of lysosomes is not restricted to protein degradation: they also fuse with the plasma membrane during cell injury, as well as having more specialized secretory functions in some cell types.
引用
收藏
页码:622 / 632
页数:11
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