Application of MnO2 nanoparticles as an eliminator of ascorbate interference to amperometric glucose biosensors

被引:95
作者
Xu, JJ [1 ]
Luo, XL [1 ]
Du, Y [1 ]
Chen, HY [1 ]
机构
[1] Nanjing Univ, Dept Chem, Key Lab Analyt Chem Life Sci, Nanjing 210093, Peoples R China
基金
中国国家自然科学基金;
关键词
chitosan; MnO2; nanoparticles; interference; glucose biosensor; ascorbic acid;
D O I
10.1016/j.elecom.2004.09.015
中图分类号
O646 [电化学、电解、磁化学];
学科分类号
081704 ;
摘要
A chitosan film containing MnO2 nanoparticles was introduced to amperometric glucose biosensors for the elimination of the interference from ascorbic acid. Chitosan was mixed with MnO2 nanoparticles and electrochemically deposited on electrodes previously modified with glucose oxidase. MnO2 nanoparticles incorporated in the chitosan film was very stable and can effectively oxidize AA to electrochemical inactive product, and thus eliminate the interference of AA on the glucose biosensors based on the direct oxidation of hydrogen peroxide. The effect of the content of MnO2 nanoparticles and the deposition time on the characteristics of the film, as well as the stability of the film during continuous exposure to AA was investigated. Glucose biosensors deposited with the film containing MnO2 nanoparticles were suitable for determination of glucose in the presence of AA. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:1169 / 1173
页数:5
相关论文
共 22 条
  • [1] Layer-by-layer construction of enzyme multilayers on an electrode for the preparation of glucose and lactate sensors: Elimination of ascorbate interference by means of an ascorbate oxidase multilayer
    Anzai, J
    Takeshita, H
    Kobayashi, Y
    Osa, T
    Hoshi, T
    [J]. ANALYTICAL CHEMISTRY, 1998, 70 (04) : 811 - 817
  • [2] Preparation, characterization and application of alkanethiol self-assembled monolayers modified with tetrathiafulvalene and glucose oxidase at a gold disk electrode
    Campuzano, S
    Gálvez, R
    Pedero, M
    de Villena, FJM
    Pingarrón, JM
    [J]. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2002, 526 (1-2): : 92 - 100
  • [3] Amperometric biosensors employing an insoluble oxidant as an interference-removing agent
    Choi, SH
    Lee, SD
    Shin, JH
    Ha, J
    Nam, H
    Cha, GS
    [J]. ANALYTICA CHIMICA ACTA, 2002, 461 (02) : 251 - 260
  • [4] A disposable amperometric sensor screen printed on a nitrocellulose strip: A glucose biosensor employing lead oxide as an interference-removing agent
    Cui, G
    Kim, SJ
    Choi, SH
    Nam, H
    Cha, GS
    Paeng, KJ
    [J]. ANALYTICAL CHEMISTRY, 2000, 72 (08) : 1925 - 1929
  • [5] Redox enzyme linked electrochemical sensors: Theory meets practice
    Hall, EAH
    Gooding, JJ
    Hall, CE
    [J]. MIKROCHIMICA ACTA, 1995, 121 (1-4) : 119 - 145
  • [6] Selective permeation of hydrogen peroxide through polyelectrolyte multilayer films and its use for amperometric biosensors
    Hoshi, T
    Saiki, H
    Kuwazawa, S
    Tsuchiya, C
    Chen, Q
    Anzai, J
    [J]. ANALYTICAL CHEMISTRY, 2001, 73 (21) : 5310 - 5315
  • [7] Amperometric biosensor for glutamate using Prussian Blue-based "artificial peroxldase" as a transducer for hydrogen peroxide
    Karyakin, AA
    Karyakina, EE
    Gorton, L
    [J]. ANALYTICAL CHEMISTRY, 2000, 72 (07) : 1720 - 1723
  • [8] Bioelectrocatalytical glucose oxidation with phenoxazine modified glucose oxidase
    Krikstopaitis, K
    Kulys, J
    Tetianec, L
    [J]. ELECTROCHEMISTRY COMMUNICATIONS, 2004, 6 (04) : 331 - 336
  • [9] Ascorbic acid sensor based on ion-sensitive field-effect transistor modified with MnO2 nanoparticles
    Luo, XL
    Xu, JJ
    Zhao, W
    Chen, HY
    [J]. ANALYTICA CHIMICA ACTA, 2004, 512 (01) : 57 - 61
  • [10] LUO XL, IN PRESS ANAL BIOCH, P6382