The DEAD-box p68/p72 proteins and the noncoding RNA steroid receptor activator SRA - Eclectic regulators of disparate biological functions

被引:33
作者
Caretti, Giuseppina
Lei, Elissa P.
Sartorelli, Vittorio
机构
[1] NIAMS, Lab Muscle Stem Cells & Gene Regulat, NIH, Bethesda, MD 20892 USA
[2] NIDDK, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA
关键词
RNA helicases; noncoding RNA; transcription; nuclear hormone receptors; MyoD; Rm62; epithelial-mesenchymal transition;
D O I
10.4161/cc.6.10.4228
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
p68 and p72 are RNA-binding proteins endowed with RNA helicase and RNA-protein complex remodeling activities. One of the RNAs associated with p68/p72 is the noncoding Steroid Receptors RNA Activator (SRA). Here we review recent findings on the cellular processes regulated by either p68/p72 alone or in combination with SRA and discuss the transcriptional events influenced by these molecules.
引用
收藏
页码:1172 / 1176
页数:5
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