Identification of 3-nitro-L-tyrosine, a product of nitric oxide and superoxide, as an indicator of oxidative stress in the human brain

被引:43
作者
Maruyama, W
Hashizume, Y
Matsubara, K
Naoi, M
机构
[1] NAGOYA INST TECHNOL, DEPT BIOSCI, SHOWA KU, NAGOYA, AICHI 466, JAPAN
[2] NAGOYA UNIV, SCH MED, DEPT NEUROL, SHOWA KU, NAGOYA, AICHI 466, JAPAN
[3] AICHI MED UNIV, INST MED SCI AGING, NAGAKUTE, AICHI 48011, JAPAN
[4] SHIMANE MED UNIV, DEPT LEGAL MED, IZUMO, SHIMANE 693, JAPAN
来源
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 1996年 / 676卷 / 01期
关键词
3-nitro-L-tyrosine; nitric oxide; superoxide;
D O I
10.1016/0378-4347(95)00400-9
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
3-Nitro-L-tyrosine synthesized from L-tyrosine by peroxynitrite, a product of superoxide and nitric oxide, was identified for the first time in human brains. By quantitative analysis using high-performance liquid chromatography with multi-electrochemical detectors, 3-nitro-L-tyrosine concentration in the gray matter was higher in the cerebrum than in the cerebellum; 0.96 and 0.29 nmol/g wet weight, respectively. On the other hand, L-tyrosine concentration was not different. 3-Nitro-L-tyrosine in the brain may be used as an indicator of oxidative stress induced by reactive oxygen species and nitric oxide.
引用
收藏
页码:153 / 158
页数:6
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