Association between CYP2E1 polymorphisms and susceptibility to prostate cancer

Several genetic alterations have been associated with sporadic prostate cancer (PCa). In this study, the association between Rsal and Dral polymorphisms of CYP2E1 and PCa risk was analysed in a case-control study of 227 individuals using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Regarding Dral polymorphisms, the DD genotype is over-represented in PCa cases when compared with the control group (odds ratio (OR) 2.12; 95% confidence interval (CI) 1.11-4.05; P = 0.022). Regarding the Rsal polymorphism, no significant differences were found. The results of this study indicate that Dral polymorphisms of the CYP2E1 gene may be associated with a twofold increased risk for the development of PCa. (C) 2003 Lippincott Williams Wilkins.