Association between CYP2E1 polymorphisms and susceptibility to prostate cancer

被引：31

作者：

Ferreira, PM

Medeiros, R

Vasconcelos, A

Costa, S

Pinto, D

Morais, A

Oliveira, J

Lopes, C

机构：

[1] Inst Portugues Oncol Francisco Gentil, Unit Mol Oncol, P-4200072 Oporto, Portugal

[2] Inst Portugues Oncol Francisco Gentil, Dept Urol, P-4200072 Oporto, Portugal

来源：

EUROPEAN JOURNAL OF CANCER PREVENTION | 2003年 / 12卷 / 03期

关键词：

chromosome; 10; CYP2E1; genetic polymorphisms; PCR-RFLP; prostate cancer;

D O I：

10.1097/00008469-200306000-00007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several genetic alterations have been associated with sporadic prostate cancer (PCa). In this study, the association between Rsal and Dral polymorphisms of CYP2E1 and PCa risk was analysed in a case-control study of 227 individuals using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Regarding Dral polymorphisms, the DD genotype is over-represented in PCa cases when compared with the control group (odds ratio (OR) 2.12; 95% confidence interval (CI) 1.11-4.05; P = 0.022). Regarding the Rsal polymorphism, no significant differences were found. The results of this study indicate that Dral polymorphisms of the CYP2E1 gene may be associated with a twofold increased risk for the development of PCa. (C) 2003 Lippincott Williams Wilkins.

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收藏

页码：205 / 211

页数：7

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