Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV

被引：71

作者：

Moore, PS ^{[1
]}

Chang, Y ^{[1
]}

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Pathol, New York, NY 10032 USA

来源：

TRENDS IN GENETICS | 1998年 / 14卷 / 04期

关键词：

D O I：

10.1016/S0168-9525(98)01408-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A common feature of many tumor viruses is that they possess genes that produce specific proteins to inhibit major cellular tumor-suppressor pathways. Despite intensive studies, the reasons why these diverse and unrelated viruses have independently evolved oncogenes remains obscure. Kaposi-sarcoma-associated herpesvirus (KSHV or HHV8) has pirated a number of recognizable cellular genes that are key to cell survival and proliferation In this review we provide an overview of the known activities of these viral genes and show that many of these pirated proteins affect the same cellular pathways targeted by other, unrelated tumor viruses. We speculate that tumor-suppressor pathways are used by the cell as a primary defense against persistent virus infection in addition to their well-known activity in regulating cell proliferation.

引用

页码：144 / 150

页数：7

共 74 条

[1] TRANSCRIPTIONAL CONTROL BY E2F [J].

ADAMS, PD ;

KAELIN, WG .

SEMINARS IN CANCER BIOLOGY, 1995, 6 (02) :99-108

[2] Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation [J].

Arvanitakis, L ;

GerasRaaka, E ;

Varma, A ;

Gershengorn, MC ;

Cesarman, E .

NATURE, 1997, 385 (6614) :347-350

[3]

Baba M, 1996, INT J CANCER, V66, P124, DOI 10.1002/(SICI)1097-0215(19960328)66:1<124::AID-IJC21>3.0.CO

[4]

2-C

[5] G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator [J].

Bais, C ;

Santomasso, B ;

Coso, O ;

Arvanitakis, L ;

Raaka, EG ;

Gutkind, JS ;

Asch, AS ;

Cesarman, E ;

Gerhengorn, MC ;

Mesri, EA .

NATURE, 1998, 391 (6662) :86-89

[6] Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis [J].

Bertin, J ;

Armstrong, RC ;

Ottilie, S ;

Martin, DA ;

Wang, Y ;

Banks, S ;

Wang, GH ;

Senkevich, TG ;

Alnemri, ES ;

Moss, B ;

Lenardo, MJ ;

Tomaselli, KJ ;

Cohen, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (04) :1172-1176

[7] EPSTEIN-BARR VIRUS-INDUCED GENES - 1ST LYMPHOCYTE-SPECIFIC G-PROTEIN-COUPLED PEPTIDE RECEPTORS [J].

BIRKENBACH, M ;

JOSEFSEN, K ;

YALAMANCHILI, R ;

LENOIR, G ;

KIEFF, E .

JOURNAL OF VIROLOGY, 1993, 67 (04) :2209-2220

[8] An adenovirus mutant that replicates selectively in p53-deficient human tumor cells [J].

Bischoff, JR ;

Kim, DH ;

Williams, A ;

Heise, C ;

Horn, S ;

Muna, M ;

Ng, L ;

Nye, JA ;

SampsonJohannes, A ;

Fattaey, A ;

McCormick, F .

SCIENCE, 1996, 274 (5286) :373-376

[9] Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines [J].

Boshoff, C ;

Endo, Y ;

Collins, PD ;

Takeuchi, Y ;

Reeves, JD ;

Schweickart, VL ;

Siani, MA ;

Sasaki, T ;

Williams, TJ ;

Gray, PW ;

Moore, PS ;

Chang, Y ;

Weiss, RA .

SCIENCE, 1997, 278 (5336) :290-294

[10] Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma [J].

Cesarman, E ;

Nador, RG ;

Bai, F ;

Bohenzky, RA ;

Russo, JJ ;

Moore, PS ;

Chang, Y ;

Knowles, DM .

JOURNAL OF VIROLOGY, 1996, 70 (11) :8218-8223

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