Adaptation in cyclic AMP signalling processes: A central role for cyclic AMP phosphodiesterases

被引:78
作者
Houslay, MD [1 ]
机构
[1] Univ Glasgow, IBLS, Dept Biochem & Mol Biol, Glasgow G12 8QQ, Lanark, Scotland
基金
英国医学研究理事会;
关键词
cyclic AMP; phosphodiesterase; protein kinase A; AKAPS; adenylate cyclase;
D O I
10.1006/scdb.1997.0221
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cyclic AMP has provided the paradigm for the second messenger concept. Recent evidence has identified a complex array of isoforms of the enzymes involved in generation, destroying and transmitting the effects of this second messenger. These proteins provide a sophisticated system for organising cAMP signal transduction in specific intracellular compartments; for allowing integration with other signalling systems and for controlling the kinetics and hence reaction characteristics of cAMP signal transduction.
引用
收藏
页码:161 / 167
页数:7
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