Adaptation in cyclic AMP signalling processes: A central role for cyclic AMP phosphodiesterases

被引：78

作者：

Houslay, MD ^{[1
]}

机构：

[1] Univ Glasgow, IBLS, Dept Biochem & Mol Biol, Glasgow G12 8QQ, Lanark, Scotland

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1998年 / 9卷 / 02期

基金：

英国医学研究理事会;

关键词：

cyclic AMP; phosphodiesterase; protein kinase A; AKAPS; adenylate cyclase;

D O I：

10.1006/scdb.1997.0221

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cyclic AMP has provided the paradigm for the second messenger concept. Recent evidence has identified a complex array of isoforms of the enzymes involved in generation, destroying and transmitting the effects of this second messenger. These proteins provide a sophisticated system for organising cAMP signal transduction in specific intracellular compartments; for allowing integration with other signalling systems and for controlling the kinetics and hence reaction characteristics of cAMP signal transduction.

引用

页码：161 / 167

页数：7

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