Homoisoflavanones from Polygonatum odoratum Rhizomes Inhibit Advanced Glycation End Product Formation

被引：41

作者：

Dong, Wei ^{[1
,2
]}

Shi, Hai Bo ^{[1
]}

Ma, Heng ^{[1
]}

Miao, Yan Bo ^{[1
]}

Liu, Tong Jun ^{[2
]}

Wang, Wei ^{[1
]}

机构：

[1] Jilin Acad Chinese Med Sci, Inst Phytochem, Changchun 130021, Peoples R China

[2] Jilin Univ, China Japan Union Hosp, Changchun 130021, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2010年 / 33卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Polygonatum odoratum; Homoisoflavanones; Advanced glycation end-products (AGEs); Diabetic complications; AMINOGUANIDINE; IDENTIFICATION; CONSTITUENTS; PROTEINS;

D O I：

10.1007/s12272-010-0504-y

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Protein glycation inhibitors from Polygonatum odoratum rhizomes were investigated using a bioassay-guided procedure to characterize active compounds for preventing and treating diabetic complications. The EtOH extract and soluble fractions were evaluated using an in vivo model of renal advanced glycation end-product (AGE) accumulation in streptozotocin-induced diabetic rats and an in vitro bovine serum albumin-glucose assay. Three homoisoflavanones 3-(4'-hydroxybenzyl)-5,7-dihydroxy-6-methyl-8-methoxychroman-4-one (1), 3-(4'-hydroxybenzyl)-5,7-dihydroxy-6,8-dimethylchroman-4-one (2), and 3-(4'-methoxybenzyl)-5,7-dihydroxy-6-methyl-8-methoxychroman-4-one (3), isolated from the active CHCl3-soluble fraction of the EtOH extract, were subjected to in vitro bioassays to evaluate their inhibitory activities against AGE formation. All the isolates inhibited AGE formation more effectively than the positive control, aminoguanidine. These results indicate that pending further study these compounds could be used as novel natural product drug for mitigating diabetic complications.

引用

页码：669 / 674

页数：6

共 20 条

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Advanced glycation endproducts - role in pathology of diabetic complications [J].