Dosage compensation: an intertwined world of RNA and chromatin remodelling

被引：53

作者：

Akhtar, A ^{[1
]}

机构：

[1] European Mol Biol Lab, Heidelberg, Germany

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2003年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(03)00016-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dosage compensation mechanisms in flies and mammals provide an exquisite example of chromatin associated RNAs in chromosome-wide transcription regulation. Recent progress shows that chromatin modifications are also closely linked to these processes. Concerted action of the RNA/chromatin-modifying enzymes may play a crucial role in determining transcriptional output. Furthermore, non-coding RNAs appear to play a dual role, being targeting modules as well as encoding for target sites for complex recognition.

引用

页码：161 / 169

页数：9

共 59 条

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