Lactation defect in mice lacking the helix-loop-helix inhibitor Id2

被引：110

作者：

Mori, S ^{[1
]}

Nishikawa, SI ^{[1
]}

Yokota, Y ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Mol Genet, Sakyo Ku, Kyoto 6068507, Japan

来源：

EMBO JOURNAL | 2000年 / 19卷 / 21期

关键词：

apoptosis; cell proliferation; HLH inhibitor; Id2; mammary gland;

D O I：

10.1093/emboj/19.21.5772

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Id proteins are thought to be negative regulators of cell differentiation and positive regulators of cell proliferation. Mammary glands of ITd2(-/-) female mice reveal severely impaired lobulo-alveolar development during pregnancy. Id2(-/-) mammary epithelia show no precocious maturation, but instead exhibit intrinsic defects in both cell proliferation and cell survival, implying that the role of Id2 in pregnant mammary epithelia is mainly stimulation of cell proliferation and support of cell viability. Expression studies of genes required for mammary gland development suggest Id2 to be a downstream or parallel factor of these genes. A decrease in the DNA binding activity of Stat5 was also observed in Id2(-/-) mammary glands at 7 days post-coitus. Our results indicate an indispensable role of Id2 in pregnant mammary glands.

引用

页码：5772 / 5781

页数：10

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