Poly(ethylene oxide)-poly(propylene oxide) block copolymer micelles as drug delivery agents: Improved hydrosolubility, stability and bioavailability of drugs

被引：494

作者：

Chiappetta, Diego A.

Sosnik, Alejandro

机构：

[1] Univ Buenos Aires, Fac Pharm & Biochem, Dept Pharmaceut Technol, RA-1113 Buenos Aires, DF, Argentina

[2] Consejo Nacl Invest Cient & Tecn, Natl Sci Res Council, Buenos Aires, DF, Argentina

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2007年 / 66卷 / 03期

关键词：

poly(ethylene oxide)-poly(propylene oxide) block copolymers; poloxamer; poloxamine; drug solubilization; drug stability; bioavailability; drug delivery; SALT-INDUCED MICELLIZATION; PLURONIC(R) F-127 GELS; IN-VIVO EVALUATION; AQUEOUS-SOLUTIONS; POLYMERIC MICELLES; ETHYLENE-OXIDE; AGGREGATION TRANSITIONS; TRIBLOCK COPOLYMERS; CONTROLLED-RELEASE; POLOXAMER; 407;

D O I：

10.1016/j.ejpb.2007.03.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The low solubility in biological fluids displayed by about 50% of the drugs still remains the main limitation in oral, parenteral, and transdermal administration. Among the existing strategies to overcome these drawbacks, inclusion of hydrophobic drugs into polymeric micelles is one of the most attractive alternatives. Amphiphilic poly(ethylene oxide)-poly(propylene oxide) block copolymers are thermoresponsive materials that display unique aggregation properties in aqueous medium. Due to their ability to form stable micellar systems in water, these materials are broadly studied as hydrosolubilizers for poorly water-soluble drugs. The present review provides a concise description of the most important applications of PEO-PPO-based copolymers in the Pharmaceutical Technology field as means for attaining improved solubility, stability, release, and bioavailability of drugs. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：303 / 317

页数：15

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