Self glycosphingolipids: New antigens recognized by autoreactive T lymphocytes

被引：10

作者：

De Libero, G ^{[1
]}

Mori, L ^{[1
]}

机构：

[1] Univ Basel Hosp, Dept Res, CH-4031 Basel, Switzerland

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2003年 / 18卷

关键词：

D O I：

10.1152/nips.01418.2002

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

T cells may recognize glycolipids and lipids of bacterial and self origin associated with the CD1 antigen-presenting molecules. Understanding the mechanisms governing CD1-self glycolipid interaction will provide information on the molecular rules of glycolipid presentation and suggest new approaches to immunotherapy.

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收藏

页码：71 / 76

页数：6

相关论文

共 18 条

[1] RECOGNITION OF A LIPID ANTIGEN BY CD1-RESTRICTED ALPHA-BETA(+) T-CELLS [J].

BEEKMAN, EM ;

PORCELLI, SA ;

MORITA, CT ;

BEHAR, SM ;

FURLONG, ST ;

BRENNER, MB .

NATURE, 1994, 372 (6507) :691-694

[2] A SUBSET OF CD4(+) THYMOCYTES SELECTED BY MHC CLASS-I MOLECULES [J].

BENDELAC, A ;

KILLEEN, N ;

LITTMAN, DR ;

SCHWARTZ, RH .

SCIENCE, 1994, 263 (5154) :1774-1778

[3] CD1 RECOGNITION BY MOUSE NK1(+) T-LYMPHOCYTES [J].

BENDELAC, A ;

LANTZ, O ;

QUIMBY, ME ;

YEWDELL, JW ;

BENNINK, JR ;

BRUTKIEWICZ, RR .

SCIENCE, 1995, 268 (5212) :863-865

[4] 2 CLASSES OF CD1 GENES [J].

CALABI, F ;

JARVIS, JM ;

MARTIN, L ;

MILSTEIN, C .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (02) :285-292

[5] Sentinel function of broadly reactive human gamma delta T cells [J].

DeLibero, G .

IMMUNOLOGY TODAY, 1997, 18 (01) :22-26

[6] Molecular interaction of CD1b with lipoglycan antigens [J].

Ernst, WA ;

Maher, J ;

Cho, SG ;

Niazi, KR ;

Chatterjee, D ;

Moody, DB ;

Besra, GS ;

Watanabe, Y ;

Jensen, PE ;

Porcelli, SA ;

Kronenberg, M ;

Modlin, RL .

IMMUNITY, 1998, 8 (03) :331-340

[7] CD1d-restricted and TCR-mediated activation of V(alpha)14 NKT cells by glycosylceramides [J].

Kawano, T ;

Cui, JQ ;

Koezuka, Y ;

Toura, I ;

Kaneko, Y ;

Motoki, K ;

Ueno, H ;

Nakagawa, R ;

Sato, H ;

Kondo, E ;

Koseki, H ;

Taniguchi, M .

SCIENCE, 1997, 278 (5343) :1626-1629

[8] Molecular recognition of human CD1b antigen complexes:: Evidence for a common pattern of interaction with αβ TCRs [J].

Melián, A ;

Watts, GFM ;

Shamshiev, A ;

De Libero, G ;

Clatworthy, A ;

Vincent, M ;

Brenner, MB ;

Behar, S ;

Niazi, K ;

Modlin, RL ;

Almo, S ;

Ostrov, D ;

Nathenson, SG ;

Porcelli, SA .

JOURNAL OF IMMUNOLOGY, 2000, 165 (08) :4494-4504

[9] Glycolipid targets of CD1-mediated T-cell responses [J].

Moody, DB ;

Besra, GS .

IMMUNOLOGY, 2001, 104 (03) :243-251

[10] ANALYSIS OF T-CELL ANTIGEN RECEPTOR (TCR) EXPRESSION BY HUMAN PERIPHERAL-BLOOD CD4-8-ALPHA/BETA T-CELLS DEMONSTRATES PREFERENTIAL USE OF SEVERAL V-BETA GENES AND AN INVARIANT TCR ALPHA-CHAIN [J].

PORCELLI, S ;

YOCKEY, CE ;

BRENNER, MB ;

BALK, SP .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (01) :1-16