Alternative pre-mRNA splicing:: the logic of combinatorial control

被引：724

作者：

Smith, CWJ

Valcárcel, J

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

[2] European Mol Biol Lab, Gene Express Biol Lab, D-69117 Heidelberg, Germany

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/S0968-0004(00)01604-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alternative splicing of mRNA precursors is a versatile mechanism of gene expression regulation that accounts for a considerable proportion of proteomic complexity in higher eukaryotes, Its modulation is achieved through the combinatorial interplay of positive and negative regulatory signals present in the RNA, which are recognized by complexes composed of members of the hnRNP and SR protein families.

引用

页码：381 / 388

页数：8

共 54 条

[1] Biochemistry and regulation of pre-mRNA splicing [J].