Virulence factor regulation and regulatory networks in Streptococcus pyogenes and their impact on pathogen-host interactions

被引:242
作者
Kreikemeyer, B
McIver, KS
Podbielski, A
机构
[1] Univ Hosp Rostock, Dept Med Microbiol & Hosp Hyg, D-18055 Rostock, Germany
[2] Univ Texas, SW Med Ctr, Dept Microbiol, Dallas, TX 75390 USA
关键词
D O I
10.1016/S0966-842X(03)00098-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Streptococcus pyogenes (group A streptococcus, GAS) is a very important human pathogen with remarkable adaptation capabilities. Survival within the harsh host surroundings requires sensing potential on the bacterial side, which leads in particular to coordinately regulated virulence factor expression. GAS 'stand-alone' response regulators (RRs) and two-component signal transduction systems (TCSs) link the signals from the host environment with adaptive responses of the bacterial cell. Numerous putative regulatory systems emerged from GAS genome sequences. Only three RRs [Mga, RofA-like protein (RALP) and Rgg/RopB] and three TCSs (CsrRS/CovRS, FasBCAX and Ihk/lrr) have been studied in some detail with respect to their growth-phase-dependent activity and their influence on GAS-host cell interaction. In particular, the Mga-, RALP- and Rgg/RopB-regulated pathways display interconnected activities that appear to influence GAS colonization, persistence and spreading mechanisms, in a growth-phase-related fashion. Here, we have summarized our current knowledge about these RRs and TCSs to highlight the questions that should be addressed in future research on GAS pathogenicity.
引用
收藏
页码:224 / 232
页数:9
相关论文
共 68 条
[1]   Short-course antibiotic treatment of 4782 culture-proven cases of group A streptococcal tonsillopharyngitis and incidence of poststreptococcal sequelae [J].
Adam, D ;
Scholz, H ;
Helmerking, M .
JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (02) :509-516
[2]   How bacteria talk to each other: regulation of gene expression by quorum sensing [J].
Bassler, BL .
CURRENT OPINION IN MICROBIOLOGY, 1999, 2 (06) :582-587
[3]   Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi [J].
Bassler, BL ;
Greenberg, EP ;
Stevens, AM .
JOURNAL OF BACTERIOLOGY, 1997, 179 (12) :4043-4045
[4]   Group A streptococcal rofA gene is involved in the control of several virulence genes and eukaryotic cell attachment and internalization [J].
Beckert, S ;
Kreikemeyer, B ;
Podbielski, A .
INFECTION AND IMMUNITY, 2001, 69 (01) :534-537
[5]   Genome sequence of a serotype M3 strain of group A Streptococcus:: Phage-encoded toxins, the high-virulence phenotype, and clone emergence [J].
Beres, SB ;
Sylva, GL ;
Barbian, KD ;
Lei, BF ;
Hoff, JS ;
Mammarella, ND ;
Liu, MY ;
Smoot, JC ;
Porcella, SF ;
Parkins, LD ;
Campbell, DS ;
Smith, TM ;
McCormick, JK ;
Leung, DYM ;
Schlievert, PM ;
Musser, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) :10078-10083
[6]   Expression of different group A streptococcal M proteins in an isogenic background demonstrates diversity in adherence to and invasion of eukaryotic cells [J].
Berkower, C ;
Ravins, M ;
Moses, AE ;
Hanski, E .
MOLECULAR MICROBIOLOGY, 1999, 31 (05) :1463-1475
[7]   Characterization of a two-component system in Streptococcus pyogenes which is involved in regulation of hyaluronic acid production [J].
Bernish, B ;
van de Rijn, I .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (08) :4786-4793
[8]  
Bessen DE, 2000, GRAM-POSITIVE PATHOGENS, P117
[9]   Genomic localization of a T serotype locus to a recombinatorial zone encoding extracellular matrix-binding proteins in Streptococcus pyogenes [J].
Bessen, DE ;
Kalia, A .
INFECTION AND IMMUNITY, 2002, 70 (03) :1159-1167
[10]  
BODBIELSKI A, IN PRESS INT J MED M