Group A streptococcal rofA gene is involved in the control of several virulence genes and eukaryotic cell attachment and internalization

被引：60

作者：

Beckert, S ^{[1
]}

Kreikemeyer, B ^{[1
]}

Podbielski, A ^{[1
]}

机构：

[1] Univ Hosp Ulm, Dept Med Microbiol, D-89081 Ulm, Germany

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 01期

关键词：

D O I：

10.1128/IAI.69.1.534-537.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The serotype M6 group A streptococcal RofA regulator was previously shown to exert a direct positive control of protein F1 expression and, concomitantly, fibronectin binding. Using a serotype M6 rofA mutant, we demonstrate here that this regulator has a potentially indirect negative influence on the expression of the mga, emm6 pel-sagA, and speA virulence genes. Additionally, the rofA mutant exhibited reduced eukaryotic cell internalization rates in combination with decreased host cell viability.

引用

页码：534 / 537

页数：4

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