Differential Modeling of Fragile X Syndrome by Human Embryonic Stem Cells and Induced Pluripotent Stem Cells

被引:301
作者
Urbach, Achia [1 ,2 ,3 ,5 ,6 ]
Bar-Nur, Ori [4 ]
Daley, George Q. [1 ,2 ,3 ,5 ,6 ]
Benvenisty, Nissim [4 ]
机构
[1] Childrens Hosp, Howard Hughes Med Inst, Manton Ctr Orphan Dis Res, Stem Cell Transplantat Program,Div Pediat Hematol, Boston, MA 02115 USA
[2] Dana Farber Canc Inst, Boston, MA 02115 USA
[3] Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA
[4] Hebrew Univ Jerusalem, Dept Genet, Inst Life Sci, Stem Cell Unit, IL-91904 Jerusalem, Israel
[5] Harvard Univ, Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
[6] Harvard Stem Cell Inst, Boston, MA 02115 USA
基金
美国国家卫生研究院; 以色列科学基金会;
关键词
FMR1; GENE; METHYLATION; INSTABILITY; DISEASE; ALLELE; GENERATION; LENGTH;
D O I
10.1016/j.stem.2010.04.005
中图分类号
Q813 [细胞工程];
学科分类号
摘要
引用
收藏
页码:407 / 411
页数:5
相关论文
共 44 条
[1]   Induced pluripotent stem cells: current progress and potential for regenerative medicine [J].
Amabile, Giovanni ;
Meissner, Alexander .
TRENDS IN MOLECULAR MEDICINE, 2009, 15 (02) :59-68
[2]   Adaptation to culture of human embryonic stem cells and oncogenesis in vivo [J].
Baker, Duncan E. C. ;
Harrison, Neil J. ;
Maltby, Edna ;
Smith, Kath ;
Moore, Harry D. ;
Shaw, Pamela J. ;
Heath, Paul R. ;
Holden, Hazel ;
Andrews, Peter W. .
NATURE BIOTECHNOLOGY, 2007, 25 (02) :207-215
[3]   VIEWPOINT Induced pluripotent stem cells and reprogramming: seeing the science through the hype [J].
Belmonte, Juan Carlos Izpisua ;
Ellis, James ;
Hochedlinger, Konrad ;
Yamanaka, Shinya .
NATURE REVIEWS GENETICS, 2009, 10 (12) :878-U80
[4]   FMR1 premutation allele (CGG)(81) is stable in mice [J].
Bontekoe, CJM ;
deGraaff, E ;
Nieuwenhuizen, IM ;
Willemsen, R ;
Oostra, BA .
EUROPEAN JOURNAL OF HUMAN GENETICS, 1997, 5 (05) :293-298
[5]   Quantitative high-resolution CpG island mapping with Pyrosequencing™ reveals disease-specific methylation patterns of the CDKN2B gene in Myelodysplastic syndrome and myeloid leukemia [J].
Brakensiek, Kai ;
Wingen, Luzie U. ;
Langer, Florian ;
Kreipe, Hans ;
Lehmann, Ulrich .
CLINICAL CHEMISTRY, 2007, 53 (01) :17-23
[6]   Fully expanded FMR1 CGG repeats exhibit a length- and differentiation-dependent instability in cell hybrids that is independent of DNA methylation [J].
Burman, RW ;
Popovich, BW ;
Jacky, PB ;
Turker, MS .
HUMAN MOLECULAR GENETICS, 1999, 8 (12) :2293-2302
[7]   Hypomethylation of an expanded FMR1 allele is not associated with a global DNA methylation defect [J].
Burman, RW ;
Yates, PA ;
Green, LD ;
Jacky, PB ;
Turker, MS ;
Popovich, BW .
AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (05) :1375-1386
[8]   Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells [J].
Chan, Elayne M. ;
Ratanasirintrawoot, Sutheera ;
Park, In-Hyun ;
Manos, Philip D. ;
Loh, Yuin-Han ;
Huo, Hongguang ;
Miller, Justine D. ;
Hartung, Odelya ;
Rho, Junsung ;
Ince, Tan A. ;
Daley, George Q. ;
Schlaeger, Thorsten M. .
NATURE BIOTECHNOLOGY, 2009, 27 (11) :1033-U100
[9]   Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile X syndrome [J].
Coffee, B ;
Zhang, FP ;
Ceman, S ;
Warren, ST ;
Reines, D .
AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (04) :923-932
[10]   Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells [J].
Coffee, B ;
Zhang, FP ;
Warren, ST ;
Reines, D .
NATURE GENETICS, 1999, 22 (01) :98-101