IP3 receptors in cell survival and apoptosis:: Ca2+ release and beyond

被引：135

作者：

Joseph, Suresh K. ^{[1
]}

Hajnoczky, Gyorgy ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Pathol & Cell Biol, Philadelphia, PA 19107 USA

来源：

APOPTOSIS | 2007年 / 12卷 / 05期

关键词：

apoptosis; calcium; endoplasmic reticulum; IP3; receptor; mitochondria;

D O I：

10.1007/s10495-007-0719-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) serve to discharge Ca2+ from ER stores in response to agonist stimulation. The present review summarizes the role of these receptors in models of Ca2+-dependent apoptosis. In particular we focus on the regulation of IP(3)Rs by caspase-3 cleavage, cytochrome c, anti-apoptotic proteins and Akt kinase. We also address the evidence that some of the effects of IP(3)Rs in apoptosis may be independent of their ion-channel function. The role of IP(3)Rs in delivering Ca2+ to the mitochondria is discussed from the perspective of the factors determining inter-organellar dynamics and the spatial proximity of mitochondria and ER membranes.

引用

页码：951 / 968

页数：18

共 170 条

[21] Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol [J].

Breckenridge, DG ;

Stojanovic, M ;

Marcellus, RC ;

Shore, GC .

JOURNAL OF CELL BIOLOGY, 2003, 160 (07) :1115-1127

[22] Regulation of apoptosis by endoplasmic reticulum pathways [J].

Breckenridge, DG ;

Germain, M ;

Mathai, JP ;

Nguyen, M ;

Shore, GC .

ONCOGENE, 2003, 22 (53) :8608-8618

[23] Agonist-induced regulation of mitochondrial and endoplasmic reticulum motility [J].

Brough, D ;

Schell, MJ ;

Irvine, RF .

BIOCHEMICAL JOURNAL, 2005, 392 (02) :291-297

[24] Dying for NF-κB?: Control of cell death by transcriptional regulation of the apoptotic machinery [J].

Burstein, E ;

Duckett, CS .

CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (06) :732-737

[25] The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis [J].

Cai, Chuanxi ;

Lin, Peihui ;

Cheung, King-Ho ;

Li, Na ;

Levchook, Christina ;

Pan, Zui ;

Ferrante, Christopher ;

Boulianne, Gabrielle L. ;

Foskett, J. Kevin ;

Danielpour, David ;

Ma, Jianjie .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (24) :16649-16655

[26] Calcium leak from intracellular stores - the enigma of calcium signalling [J].

Camello, C ;

Lomax, R ;

Petersen, OH ;

Tepikin, AV .

CELL CALCIUM, 2002, 32 (5-6) :355-361

[27] Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion [J].

Chen, M ;

He, HP ;

Zhan, SX ;

Krajewski, S ;

Reed, JC ;

Gottlieb, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (33) :30724-30728

[28] Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate [J].

Chen, R ;

Valencia, I ;

Zhong, F ;

McColl, KS ;

Roderick, HL ;

Bootman, MD ;

Berridge, MJ ;

Conway, SJ ;

Holmes, AB ;

Mignery, GA ;

Velez, P ;

Distelhorst, CW .

JOURNAL OF CELL BIOLOGY, 2004, 166 (02) :193-203

[29] Mitochondrial Ca2+ uptake depends on the spatial and temporal profile of cytosolic Ca2+ signals [J].

Collins, TJ ;

Lipp, P ;

Berridge, MJ ;

Bootman, MD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (28) :26411-26420

[30] tcBid promotes Ca2+ signal propagation to the mitochondria:: control of Ca2+ permeation through the outer mitochondrial membrane [J].

Csordás, G ;

Madesh, M ;

Antonsson, B ;

Hajnóczky, G .

EMBO JOURNAL, 2002, 21 (09) :2198-2206

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