Immunological ignorance of silent antigens as an explanation of tumor evasion

Although there is little doubt about the existence of tumor antigens that can be recognized by cytotoxic T lymphocytes in common human cancers, it is still unclear why these antigens do not cause tumor rejection. Here, Lieping Chen proposes that immunological ignorance of silent antigens might explain the inefficient T-cell response to cancer, and suggests how this may be overcome.