Immunological ignorance of silent antigens as an explanation of tumor evasion

被引：80

作者：

Chen, LP

机构：

[1] Mayo Clin & Mayo Fdn, Dept Immunol, Rochester, MN 55905 USA

[2] Bristol Myers Squibb Pharmaceut Res Inst, Seattle, WA 98121 USA

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 01期

关键词：

D O I：

10.1016/S0167-5699(97)01180-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although there is little doubt about the existence of tumor antigens that can be recognized by cytotoxic T lymphocytes in common human cancers, it is still unclear why these antigens do not cause tumor rejection. Here, Lieping Chen proposes that immunological ignorance of silent antigens might explain the inefficient T-cell response to cancer, and suggests how this may be overcome.

引用

页码：27 / 30

页数：4

共 52 条

[11] DOLDEVILA G, 1995, J IMMUNOL, V155, P5590
[12] Loss of a unique tumor antigen by cytotoxic T lymphocyte immunoselection from a 3-methylcholanthrene-induced mouse sarcoma reveals secondary unique and shared antigens
Dudley, ME
Roopenian, DC
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) : 441 - 447
[13] Immunodominance of cytotoxic T lymphocyte epitopes co-injected in vivo and modulation by interleukin-12
Eberl, G
Kessler, B
Eberl, LP
Brunda, MJ
Valmori, D
Corradin, G
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (11) : 2709 - 2716
[14] FEARON ER, 1988, CANCER RES, V48, P2975
[15] HLA class I antigens in human tumors
Garrido, F
Cabrera, T
LopezNevot, MA
RuizCabello, F
[J]. ADVANCES IN CANCER RESEARCH, VOL 67, 1995, 67 : 155 - 195
[16] MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I ALLELE-SPECIFIC PEPTIDE LIBRARIES - IDENTIFICATION OF PEPTIDES THAT MIMIC AN H-Y T-CELL EPITOPE
GAVIN, MA
DERE, B
GRANDEA, AG
HOGQUIST, KA
BEVAN, MJ
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (09) : 2124 - 2133
[17] FAS LIGAND-INDUCED APOPTOSIS AS A MECHANISM OF IMMUNE PRIVILEGE
GRIFFITH, TS
BRUNNER, T
FLETCHER, SM
GREEN, DR
FERGUSON, TA
[J]. SCIENCE, 1995, 270 (5239) : 1189 - 1192
[18] E7 oncoprotein of human papillomavirus type 16 expressed constitutively in the epidermis has no effect on E7-specific B- or Th-repertoires or on the immune response induced or sustained after immunization with E7 protein
Herd, K
Fernando, GJP
Dunn, LA
Frazer, IH
Lambert, P
Tindle, RW
[J]. VIROLOGY, 1997, 231 (01) : 155 - 165
[19] Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells
Hsu, FJ
Benike, C
Fagnoni, F
Liles, TM
Czerwinski, D
Taidi, B
Engleman, EG
Levy, R
[J]. NATURE MEDICINE, 1996, 2 (01) : 52 - 58
[20] AN EVALUATION OF THE POTENTIAL TO USE TUMOR-ASSOCIATED ANTIGENS AS TARGETS FOR ANTITUMOR T-CELL THERAPY USING TRANSGENIC MICE EXPRESSING A RETROVIRAL TUMOR-ANTIGEN IN NORMAL LYMPHOID-TISSUES
HU, J
KINDSVOGEL, W
BUSBY, S
BAILEY, MC
SHI, YY
GREENBERG, PD
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (06) : 1681 - 1690

← 1 2 3 4 5 6 →