Bisphenol-A: a new diabetogenic factor?

被引：80

作者：

Alonso-Magdalena, Paloma ^{[1
,2
]}

Belin Ropero, Ana ^{[1
,2
]}

Soriano, Sergi ^{[1
,2
]}

Quesada, Ivan ^{[1
,2
]}

Nadal, Angel ^{[1
,2
]}

机构：

[1] Univ Miguel Hernandez Elche, Inst Bioengn, Elche, Spain

[2] CIBERDEM, CIBER Diabet & Associated Metab Dis, Elche, Spain

来源：

HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM | 2010年 / 9卷 / 02期

关键词：

Bisphenol-A; Diabetes; Estradiol; Estrogen Receptors; Glucose Homeostasis; Islet of Langerhans; ESTROGEN-RECEPTOR-ALPHA; ADIPOSE-TISSUE; INSULIN-RESISTANCE; GLUCOSE-HOMEOSTASIS; INTACT ISLETS; METABOLIC SYNDROME; ENERGY-BALANCE; HUMAN EXPOSURE; CELL-FUNCTION; BODY-WEIGHT;

D O I：

10.1007/BF03401277

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this review was to analyze the potential effects of environmental chemicals on homeo-static control related to glycemia and energy balance. Many of the environmental chemicals can mimic or interfere with the action of hormones and are generally referred to as "endocrine disruptors". Among these compounds, polychlorinated biphenyls, dioxins, phthalates and bisphenol-A have been correlated with alterations in blood glucose homeostasis in humans. In rodents it has been demonstrated that small doses of bisphenol-A have profound effects on glucose metabolism. Therefore, this altered blood glucose homeostasis may enhance the development of type 2 diabetes.

引用

页码：118 / 126

页数：9

共 85 条

[1] Promoting insulin secretion in pancreatic, islets by means of bisphenol A and nonylphenol via intracellular estrogen receptors [J].

Adachi, T ;

Yasuda, K ;

Mori, C ;

Yoshinaga, M ;

Aoki, N ;

Tsujimoto, G ;

Tsuda, K .

FOOD AND CHEMICAL TOXICOLOGY, 2005, 43 (05) :713-719

[2] Screening and testing for endocrine disruption in fish - Biomarkers as "signposts," not "traffic lights," in risk assessment [J].

Hutchinson, Thomas H. ;

Ankley, Gerald T. ;

Segner, Helmut ;

Tyler, Charles R. .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2006, 114 :106-114

[3] Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic α-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans [J].

Alonso-Magdalena, P ;

Laribi, O ;

Ropero, AB ;

Fuentes, E ;

Ripoll, C ;

Soria, B ;

Nadal, A .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2005, 113 (08) :969-977

[4] Pancreatic Insulin Content Regulation by the Estrogen Receptor ERα [J].

Alonso-Magdalena, Paloma ;

Ropero, Ana B. ;

Carrera, M. Pilar ;

Cederroth, Christopher R. ;

Baquie, Mathurin ;

Gauthier, Benoit R. ;

Nef, Serge ;

Stefani, Enrico ;

Nadal, Angel .

PLOS ONE, 2008, 3 (04)

[5] Estrogen receptors:: new players in diabetes mellitus [J].

Barros, Rodrigo P. A. ;

Machado, Ubiratan Fabres ;

Gustafsson, Jan-Ake .

TRENDS IN MOLECULAR MEDICINE, 2006, 12 (09) :425-431

[6] Muscle GLUT4 regulation by estrogen receptors ERβ and ERα [J].

Barros, RPA ;

Machado, UF ;

Warner, M ;

Gustafsson, JÅ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (05) :1605-1608

[7] Suppression of Ca2+ oscillations in glucagon-producing alpha(2)-cells by insulin glucose and amino acids [J].

Berts, A ;

Ball, A ;

Gylfe, E ;

Hellman, B .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1996, 1310 (02) :212-216

[8] From mice to men: Insights into the insulin resistance syndromes [J].

Biddinger, SB ;

Kahn, CR .

ANNUAL REVIEW OF PHYSIOLOGY, 2006, 68 :123-158

[9] Bisphenol A induces reactive oxygen species generation in the liver of male rats [J].

Bindhumol, V ;

Chitra, KC ;

Mathur, PP .

TOXICOLOGY, 2003, 188 (2-3) :117-124

[10] Evidence that oestrogen receptor-α plays an important role in the regulation of glucose homeostasis in mice:: insulin sensitivity in the liver [J].

Bryzgalova, G ;

Gao, H ;

Ahren, B ;

Zierath, JR ;

Galuska, D ;

Steiler, TL ;

Dahlman-Wright, K ;

Nilsson, S ;

Gustafsson, JÅ ;

Efendic, S ;

Khan, A .

DIABETOLOGIA, 2006, 49 (03) :588-597

← 1 2 3 4 5 6 7 8 9 →