Bisphenol-A: a new diabetogenic factor?

被引：80

作者：

Alonso-Magdalena, Paloma ^{[1
,2
]}

Belin Ropero, Ana ^{[1
,2
]}

Soriano, Sergi ^{[1
,2
]}

Quesada, Ivan ^{[1
,2
]}

Nadal, Angel ^{[1
,2
]}

机构：

[1] Univ Miguel Hernandez Elche, Inst Bioengn, Elche, Spain

[2] CIBERDEM, CIBER Diabet & Associated Metab Dis, Elche, Spain

来源：

HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM | 2010年 / 9卷 / 02期

关键词：

Bisphenol-A; Diabetes; Estradiol; Estrogen Receptors; Glucose Homeostasis; Islet of Langerhans; ESTROGEN-RECEPTOR-ALPHA; ADIPOSE-TISSUE; INSULIN-RESISTANCE; GLUCOSE-HOMEOSTASIS; INTACT ISLETS; METABOLIC SYNDROME; ENERGY-BALANCE; HUMAN EXPOSURE; CELL-FUNCTION; BODY-WEIGHT;

D O I：

10.1007/BF03401277

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this review was to analyze the potential effects of environmental chemicals on homeo-static control related to glycemia and energy balance. Many of the environmental chemicals can mimic or interfere with the action of hormones and are generally referred to as "endocrine disruptors". Among these compounds, polychlorinated biphenyls, dioxins, phthalates and bisphenol-A have been correlated with alterations in blood glucose homeostasis in humans. In rodents it has been demonstrated that small doses of bisphenol-A have profound effects on glucose metabolism. Therefore, this altered blood glucose homeostasis may enhance the development of type 2 diabetes.

引用

页码：118 / 126

页数：9

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