Assessment of new 6-Cl-HOBt based coupling reagents for peptide synthesis. Part 2: Racemization studies

被引：6

作者：

Di Fenza, A ^{[1
]}

Rovero, P ^{[1
]}

机构：

[1] Univ Salerno, Dept Pharmaceut Sci, I-84100 Salerno, Italy

来源：

LETTERS IN PEPTIDE SCIENCE | 2002年 / 9卷 / 2-3期

关键词：

coupling reagents; racemization; side reactions; solid-phase peptide synthesis;

D O I：

10.1023/A:1024184715592

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel Cl-HOBt based coupling reagents have been evaluated for racemization extent in solid-phase peptide synthesis. The results show that all the coupling protocols based on the use of the novel reagents enable incorporation of the racemization prone residue serine with less than 2% racemization. Moreover, serine racemization obtained is less than 0.5% with protocols where a pre-activation step is avoided.

引用

页码：125 / 129

页数：5

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