Unravelling the stealth effect

被引：90

作者：

Butcher, Neville J. ^{[1
]}

Mortimer, Gysell M. ^{[1
]}

Minchin, Rodney F. ^{[1
]}

机构：

[1] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia

来源：

NATURE NANOTECHNOLOGY | 2016年 / 11卷 / 04期

关键词：

PEGYLATION; CLEARANCE; PROTEINS;

D O I：

10.1038/nnano.2016.6

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

Poly(ethylene glycol) helps nanomaterials evade the immune system by modifying the composition of proteins that are adsorbed on the surface of the materials.

引用

页码：310 / 311

页数：3

共 10 条

[1]

The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage [J].

Abu Lila, Amr S. ;

Kiwada, Hiroshi ;

Ishida, Tatsuhiro .

JOURNAL OF CONTROLLED RELEASE, 2013, 172 (01) :38-47

[2]

Deng ZJ, 2011, NAT NANOTECHNOL, V6, P39, DOI [10.1038/nnano.2010.250, 10.1038/NNANO.2010.250]

[3]

PEGylation of Proteins and Liposomes: a Powerful and Flexible Strategy to Improve the Drug Delivery [J].

Milla, Paola ;

Dosio, Franco ;

Cattel, Luigi .

CURRENT DRUG METABOLISM, 2012, 13 (01) :105-119

[4]

Cryptic Epitopes of Albumin Determine Mononuclear Phagocyte System Clearance of Nanomaterials [J].

Mortimer, Gysell M. ;

Butcher, Neville J. ;

Musumeci, Anthony W. ;

Deng, Zhou J. ;

Martin, Darren J. ;

Minchin, Rodney F. .

ACS NANO, 2014, 8 (04) :3357-3366

[5]

Protein-polymer conjugation - moving beyond PEGylation [J].

Qi, Yizhi ;

Chilkoti, Ashutosh .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2015, 28 :181-193

[6]

Schöttler S, 2016, NAT NANOTECHNOL, V11, P372, DOI [10.1038/NNANO.2015.330, 10.1038/nnano.2015.330]

[7]

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology [J].

Tenzer, Stefan ;

Docter, Dominic ;

Kuharev, Joerg ;

Musyanovych, Anna ;

Fetz, Verena ;

Hecht, Rouven ;

Schlenk, Florian ;

Fischer, Dagmar ;

Kiouptsi, Klytaimnistra ;

Reinhardt, Christoph ;

Landfester, Katharina ;

Schild, Hansjoerg ;

Maskos, Michael ;

Knauer, Shirley K. ;

Stauber, Roland H. .

NATURE NANOTECHNOLOGY, 2013, 8 (10) :772-U1000

[8]

PEGylation, successful approach to drug delivery [J].

Veronese, FM ;

Pasut, G .

DRUG DISCOVERY TODAY, 2005, 10 (21) :1451-1458

[9]

PEGylated proteins: Evaluation of their safety in the absence of definitive metabolism studies [J].

Webster, Rob ;

Didier, Eric ;

Harris, Philip ;

Siegel, Ned ;

Stadler, Jeanne ;

Tilbury, Lorraine ;

Smith, Dennis .

DRUG METABOLISM AND DISPOSITION, 2007, 35 (01) :9-16

[10]

Discussion about Several Potential Drawbacks of PEGylated Therapeutic Proteins [J].

Zhang, Fan ;

Liu, Mu-rong ;

Wan, Hai-tong .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2014, 37 (03) :335-339

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