Emerging molecular markers of cancer

被引：504

作者：

Sidransky, D ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 03期

关键词：

D O I：

10.1038/nrc755

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Alterations in gene sequences, expression levels and protein structure or function have been associated with every type of cancer. These 'molecular markers' can be useful in detecting cancer, determining prognosis and monitoring disease progression or therapeutic response. But what is the best way to identify molecular markers and can they be easily incorporated into the clinical setting?

引用

收藏

页码：210 / 219

页数：10

相关论文

共 100 条

[51] Loss of heterozygosity assay for molecular detection of cancer using energy-transfer primers and capillary array electrophoresis [J].

Medintz, IL ;

Lee, CCR ;

Wong, WW ;

Pirkola, K ;

Sidransky, D ;

Mathies, RA .

GENOME RESEARCH, 2000, 10 (08) :1211-1218

[52] 5' CPG ISLAND METHYLATION IS ASSOCIATED WITH TRANSCRIPTIONAL SILENCING OF THE TUMOR-SUPPRESSOR P16/CDKN2/MTS1 IN HUMAN CANCERS [J].

MERLO, A ;

HERMAN, JG ;

MAO, L ;

LEE, DJ ;

GABRIELSON, E ;

BURGER, PC ;

BAYLIN, SB ;

SIDRANSKY, D .

NATURE MEDICINE, 1995, 1 (07) :686-692

[53] DETECTION OF K-RAS ONCOGENE MUTATIONS IN BRONCHOALVEOLAR LAVAGE FLUID FOR LUNG-CANCER DIAGNOSIS [J].

MILLS, NE ;

FISHMAN, CL ;

SCHOLES, J ;

ANDERSON, SE ;

ROM, WN ;

JACOBSON, DR .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (14) :1056-1060

[54] Telomerase catalytic subunit homologs from fission yeast and human [J].

Nakamura, TM ;

Morin, GB ;

Chapman, KB ;

Weinrich, SL ;

Andrews, WH ;

Lingner, J ;

Harley, CB ;

Cech, TR .

SCIENCE, 1997, 277 (5328) :955-959

[55] Microsatellite alterations in serum DNA of head and neck cancer patients [J].

Nawroz, H ;

Koch, W ;

Anker, P ;

Stroun, M ;

Sidransky, D .

NATURE MEDICINE, 1996, 2 (09) :1035-1037

[56]

Ohara K, 2001, HEPATO-GASTROENTEROL, V48, P859

[57] Cochrane review on screening for breast cancer with mammography [J].

Olsen, O ;

Gotzsche, PC .

LANCET, 2001, 358 (9290) :1340-1342

[58]

Palmisano WA, 2000, CANCER RES, V60, P5954

[59] New technologies for biomarker analysis of prostate cancer progression: Laser capture microdissection and tissue proteomics [J].

Paweletz, CP ;

Liotta, LA ;

Petricoin, EF .

UROLOGY, 2001, 57 (4A) :160-163

[60] Use of proteomic patterns in serum to identify ovarian cancer [J].

Petricoin, EF ;

Ardekani, AM ;

Hitt, BA ;

Levine, PJ ;

Fusaro, VA ;

Steinberg, SM ;

Mills, GB ;

Simone, C ;

Fishman, DA ;

Kohn, EC ;

Liotta, LA .

LANCET, 2002, 359 (9306) :572-577

← 1 2 3 4 5 6 7 8 9 10 →