MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015

被引：163

作者：

Choe, Pyoeng Gyun ^{[1
]}

Perera, R. A. P. M. ^{[2
]}

Park, Wan Beom ^{[1
]}

Song, Kyoung-Ho ^{[1
]}

Bang, Ji Hwan ^{[1
]}

Kim, Eu Suk ^{[1
]}

Kim, Hong Bin ^{[1
]}

Ko, Long Wei Ronald ^{[2
]}

Park, Sang Won ^{[1
]}

Kim, Nam-Joong ^{[1
]}

Lau, Eric H. Y. ^{[2
]}

Poon, Leo L. M. ^{[2
]}

Peiris, Malik ^{[2
]}

Oh, Myoung-don ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Seoul, South Korea

[2] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China

来源：

EMERGING INFECTIOUS DISEASES | 2017年 / 23卷 / 07期

基金：

美国国家卫生研究院;

关键词：

RESPIRATORY SYNDROME CORONAVIRUS; SAUDI-ARABIA; DROMEDARY CAMELS; INFECTION; FEASIBILITY;

D O I：

10.3201/eid2307.170310

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the kinetics of the Middle East respiratory syndrome coronavirus (MERS-CoV) neutralizing and spike protein antibody titers over the course of 1 year in 11 patients who were confirmed by reverse transcription PCR to have been infected during the outbreak in South Korea in 2015. Robust antibody responses were detected in all survivors who had severe disease; responses remained detectable, albeit with some waning, for <= 1 year. The duration of viral RNA detection (but not viral load) in sputum significantly correlated with the antibody response magnitude. The MERS S1 ELISA antibody titers correlated well with the neutralizing antibody response. Antibody titers in 4 of 6 patients who had mild illness were undetectable even though most had evidence of pneumonia. This finding implies that MERS-CoV seroepidemiologic studies markedly underestimate the extent of mild and asymptomatic infection. Obtaining convalescent-phase plasma with high antibody titers to treat MERS will be challenging.

引用

页码：1079 / 1084

页数：6

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