Wnt/β-catenin signaling

被引：290

作者：

Akiyama, T ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Lab Mol & Genet Informat, Bunkyo Ku, Tokyo 1130032, Japan

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2000年 / 11卷 / 04期

关键词：

Wnt signaling; beta-catenin; TCF/LEF; APC; axin;

D O I：

10.1016/S1359-6101(00)00011-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Wnt/Wingless signaling transduction pathway plays an important role in both embryonic development and tumorigenesis. beta-Catenin, a key component of the Wnt signaling pathway, interacts with the TCF/LEF family of transcription factors and activates transcription of Wnt target genes. Recent studies have revealed that a number of proteins such as, the tumor suppressor APC and Axin are involved in the regulation of the Wnt signaling pathway. Furthermore, mutations in APC or beta-catenin have been found to be responsible for the genesis of human cancers. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：273 / 282

页数：10

共 110 条

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