Altered gastrin regulation in mice infected with Helicobacter felis

被引:11
作者
Dial, EJ
Hall, LR
Romero, JJ
Lechago, J
Fox, JG
Lichtenberger, LM
机构
[1] Univ Texas, Sch Med, Dept Integrat Biol Pharmacol & Physiol, Houston, TX 77225 USA
[2] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA
[3] MIT, Div Comparat Med, Cambridge, MA 02139 USA
关键词
gastrin; gastritis; Helicobacter felis; somatostatin; carcinogenesis;
D O I
10.1023/A:1005543701212
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Altered gastrin expression associated with Helicobacter pylori infection may contribute to the pathogenesis of peptic ulcer disease or gastric cancer in man, but gastrin has not been investigated in a murine model of Helicobacter infection. C57BL/6 mice were inoculated with Helicobacter felis and examined after 4-21 weeks for G and D cell numbers, antral gastrin and somatostatin mRNA, and luminal pH. In H. felis-infected mice, gastrin mRNA declined at our and six weeks after infection to 57% and 23%, respectively, of uninfected control values. Concurrently, somatostatin mRNA showed no change at four weeks and a modest 25% decrease at six weeks after infection. Similar reductions were noted in G and D cell numbers, resulting in a decrease in the G/D cell ratio after mice were infected with H. felis. Infected animals also showed a loss of parietal and chief cells, and an increased gastric pH. H. felis infection in C57BL/6 mice leads to an early suppression of G cell number and gastrin mRNA. These changes precede an alteration in somatostatin cell number and mRNA and, coupled with reductions in parietal and chief cells, may contribute both to severe impairment of gastric acid output and the potential for carcinogenic processes.
引用
收藏
页码:1308 / 1314
页数:7
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