Behind the smile: cell biology and disease mechanisms of Giardia species

被引：266

作者：

Ankarklev, Johan ^{[1
]}

Jerlstrom-Hultqvist, Jon ^{[1
]}

Ringqvist, Emma ^{[1
]}

Troell, Karin ^{[1
]}

Svard, Staffan G. ^{[1
]}

机构：

[1] Uppsala Univ, Dept Cell & Mol Biol, Biomed Ctr, SE-75124 Uppsala, Sweden

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 06期

基金：

瑞典研究理事会;

关键词：

EPITHELIAL BARRIER FUNCTION; EARLY DIVERGING EUKARYOTE; LAMBLIA CYST WALL; ANTIGENIC VARIATION; TRANSCRIPTIONAL ACTIVATION; NUCLEI; EPIGENETIC MECHANISMS; PROVIDES EVIDENCE; SURFACE PROTEIN; MEIOTIC GENES;

D O I：

10.1038/nrmicro2317

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The eukaryotic intestinal parasite Giardia intestinalis was first described in 1681, when Antonie van Leeuwenhoek undertook a microscopic examination of his own diarrhoeal stool. Nowadays, although G. intestinalis is recognized as a major worldwide contributor to diarrhoeal disease in humans and other mammals, the disease mechanisms are still poorly understood. Owing to its reduced complexity and proposed early evolutionary divergence, G. intestinalis is used as a model eukaryotic system for studying many basic cellular processes. In this Review we discuss recent discoveries in the molecular cell biology and pathogenesis of G. intestinalis.

引用

页码：413 / 422

页数：10

共 120 条

[91] snoRNA, a Novel Precursor of microRNA in Giardia lamblia [J].

Saraiya, Ashesh A. ;

Wang, Ching C. .

PLOS PATHOGENS, 2008, 4 (11)

[92] Role of CD8+ and CD4+ T lymphocytes in jejunal mucosal injury during murine Giardiasis [J].

Scott, KGE ;

Yu, LCH ;

Buret, AG .

INFECTION AND IMMUNITY, 2004, 72 (06) :3536-3542

[93] Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion [J].

Scott, KGE ;

Meddings, JB ;

Kirk, DR ;

Lees-Miller, SP ;

Buret, AG .

GASTROENTEROLOGY, 2002, 123 (04) :1179-1190

[94] ULTRASTRUCTURE OF CYST OF GIARDIA-LAMBLIA [J].

SHEFFIELD, HG ;

BJORVATN, B .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1977, 26 (01) :23-30

[95] Cytoskeletal organization, phylogenetic affinities and systematics in the contentious taxon Excavata (Eukaryota) [J].

Simpson, AGB .

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2003, 53 :1759-1777

[96] Comprehensive multigene phylogenies of excavate protists reveal the evolutionary positions of "primitive" eukaryotes [J].

Simpson, AGB ;

Inagaki, Y ;

Roger, AJ .

MOLECULAR BIOLOGY AND EVOLUTION, 2006, 23 (03) :615-625

[97] Biological selection of variant-specific surface proteins in Giardia lamblia [J].

Singer, SM ;

Elmendorf, HG ;

Conrad, JT ;

Nash, TE .

JOURNAL OF INFECTIOUS DISEASES, 2001, 183 (01) :119-124

[98] Dephosphorylation of cyst wall proteins by a secreted lysosomal acid phosphatase is essential for excystation of Giardia lamblia [J].

Slavin, I ;

Saura, A ;

Carranza, PG ;

Touz, MC ;

Nores, MJ ;

Luján, HD .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2002, 122 (01) :95-98

[99] Reductive Evolution of the Mitochondrial Processing Peptidases of the Unicellular Parasites Trichomonas vaginalis and Giardia intestinalis [J].

Smid, Ondrej ;

Matuskova, Anna ;

Harris, Simon R. ;

Kucera, Tomas ;

Novotny, Marian ;

Horvathova, Lenka ;

Hrdy, Ivan ;

Kutejova, Eva ;

Hirt, Robert P. ;

Embley, T. Martin ;

Janata, Jiri ;

Tachezy, Jan .

PLOS PATHOGENS, 2008, 4 (12)

[100] PHYLOGENETIC MEANING OF THE KINGDOM CONCEPT - AN UNUSUAL RIBOSOMAL-RNA FROM GIARDIA-LAMBLIA [J].

SOGIN, ML ;

GUNDERSON, JH ;

ELWOOD, HJ ;

ALONSO, RA ;

PEATTIE, DA .

SCIENCE, 1989, 243 (4887) :75-77

← 3 4 5 6 7 8 9 10 11 12 →