OPINION Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

被引：188

作者：

Khurana, Vikram ^{[1
,4
,5
]}

Lindquist, Susan ^{[1
,2
,3
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA USA

[3] Howard Hughes Med Inst, Chevy Chase, MD USA

[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Neurol, Boston, MA USA

[5] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurol, Boston, MA 02115 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2010年 / 11卷 / 06期

基金：

美国国家卫生研究院;

关键词：

ENDOPLASMIC-RETICULUM STRESS; ALPHA-SYNUCLEIN TOXICITY; PRPSC-LIKE CONFORMATION; POLYGLUTAMINE AGGREGATION; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE; CELLULAR TOXICITY; EXPANDED POLYGLUTAMINE; MUTANT HUNTINGTIN; TRANSGENIC MOUSE;

D O I：

10.1038/nrn2809

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In ageing populations, neurodegenerative diseases increase in prevalence, exacting an enormous toll on individuals and their communities. Multiple complementary experimental approaches are needed to elucidate the mechanisms underlying these complex diseases and to develop novel therapeutics. Here, we describe why the budding yeast Saccharomyces cerevisiae has a unique role in the neurodegeneration armamentarium. As the best-understood and most readily analysed eukaryotic organism, S. cerevisiae is delivering mechanistic insights into cell-autonomous mechanisms of neurodegeneration at an interactome-wide scale.

引用

页码：436 / 449

页数：14

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